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Which enzyme’s presence is of utmost importance for the 2nd step of sulphation?(a) Sulfotransferase(b) Amidases(c) Transferase(d) UDP-glucuronyl transferaseThis question was addressed to me in an internship interview.This intriguing question comes from Drugs Biotransformation in section Biotransformation of Drugs of Drug Biotechnology

Answer»

Right CHOICE is (a) Sulfotransferase

The best explanation: Sulfotransferase catalyses the transfer of SULPHATE group from 3’-phosphoadenosine-5’-phosphosulfate to the substrate. It ALSO helps in the LIBERATION of 3’-phosphoadenosine-5’-PHOSPHATE.



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