What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?(a) 3-4mg/ml(b) 4-6 mg/ml(c) 7-8 mg/ml(d) 1-2 mg/mlThis question was posed to me in an interview for job.My question is from Physicochemical Factors Affecting Drug Absorption in section Absorption of Drugs of Drug Biotechnology

What should be the ideal solubility rate of an orally administered dru

1.	What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?(a) 3-4mg/ml(b) 4-6 mg/ml(c) 7-8 mg/ml(d) 1-2 mg/mlThis question was posed to me in an interview for job.My question is from Physicochemical Factors Affecting Drug Absorption in section Absorption of Drugs of Drug Biotechnology
Answer» Right CHOICE is (d) 1-2 mg/ml To ELABORATE: The solubility of any orally administered DRUG should be between 1-2 mg/ml in the range of pH 2-8. The solubility BECOMES a great matter of concern if it is less than that. And if more than that the DOSAGE must be carefully calculated.

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