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What should be the range of oil/water partition coefficient of any drug?(a) 1-2(b) 3-4(c) 2-3(d) 1-3I got this question in quiz.Query is from Drugs Absorption in chapter Absorption of Drugs of Drug Biotechnology

Answer»

Right choice is (a) 1-2

Explanation: The octanol/pH 7.4 buffer partition coefficient value for a DRUG should be in the range of 1-2. This is sufficient for PASSIVE ABSORPTION ACROSS lipodial MEMBRANES.



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