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What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml?(a) 104g/min(b) 140g/min(c) 130g/min(d) 100g/minThe question was posed to me in a national level competition.I'm obligated to ask this question of Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer»

The correct choice is (a) 104g/min

The best I can explain: Clearance is expressed through the equation of elimination RATE/PLASMA drug CONCENTRATION. So, for the elimination rate, the equation BECOMES clearance * plasma drug concentration. Thus the answer becomes 130*0.8= 104 g/min.



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