What will be the fraction of unbound drug if the unbound drug concentration is 0.99 g/ml and total plasma concentration is 160 g/ml?(a) 0.006(b) 1.61(c) 0.618(d) 0.010The question was posed to me during an online interview.I need to ask this question from Drugs Excretion in section Prodrugs & Excretion of Drugs of Drug Biotechnology

What will be the fraction of unbound drug if the unbound drug concentr

1.	What will be the fraction of unbound drug if the unbound drug concentration is 0.99 g/ml and total plasma concentration is 160 g/ml?(a) 0.006(b) 1.61(c) 0.618(d) 0.010The question was posed to me during an online interview.I need to ask this question from Drugs Excretion in section Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» Correct option is (c) 0.618 Best explanation: The fraction of drug BOUND to PLASMA proteins can be calculated by the equation FU = Cu/C. Here fu is fraction of UNBOUND drug and Cu is the concentration of unbound drug in plasma and C is the total plasma concentration of the drug. Therefore 99/160=0.618.

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