What will be the unbound drug concentration if the unbound drug fraction is 0.52 and the total plasma concentration is 140 g/ml?(a) 80 g/ml(b) 82.8 g/ml(c) 70 g/ml(d) 72.8 g/mlI have been asked this question during an interview.This is a very interesting question from Drugs Excretion in portion Prodrugs & Excretion of Drugs of Drug Biotechnology

What will be the unbound drug concentration if the unbound drug fracti

1.	What will be the unbound drug concentration if the unbound drug fraction is 0.52 and the total plasma concentration is 140 g/ml?(a) 80 g/ml(b) 82.8 g/ml(c) 70 g/ml(d) 72.8 g/mlI have been asked this question during an interview.This is a very interesting question from Drugs Excretion in portion Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» Correct choice is (d) 72.8 g/ml Explanation: The FRACTION of DRUG bound to plasma proteins can be calculated by the equation fu = Cu/C. Here Fu is fraction of unbound drug and Cu is the concentration of unbound drug in plasma and C is the total plasma concentration of the drug. For the CALCULATION of unbound drug concentration, the equation will be unbound drug fraction * total plasma concentration. Thus the answer will be 0.52*140 = 72.8 g/ml.

Discussion

No Comment Found

Related InterviewSolutions

Which drugs cannot be filtered through glomerulus?(a) Drugs bound to plasma proteins(b) Unbound(c) Free drug(d) Below molecular weight of 300 DaltonThis question was posed to me during an online interview.This interesting question is from Drugs Excretion in division Prodrugs & Excretion of Drugs of Drug Biotechnology
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?(a) Drug excreted only by filtration(b) Drug filtered and actively reabsorbed(c) Drug filtered as well as actively secreted(d) Drug reabsorbed activelyThis question was addressed to me in an interview for internship.My question is from Drugs Excretion in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus.(a) True(b) FalseThis question was posed to me in an international level competition.Enquiry is from Drugs Excretion topic in portion Prodrugs & Excretion of Drugs of Drug Biotechnology
What is the equation for clearance?(a) Elimination rate / plasma drug concentration(b) Plasma drug concentration/elimination rate(c) 1 / Plasma drug concentration(d) 1 / Elimination rateThis question was posed to me during an interview.My query is from Drugs Excretion topic in section Prodrugs & Excretion of Drugs of Drug Biotechnology
In the following diagram which organ name should be in the place of ‘?’?(a) Small intestine(b) Large intestine(c) Liver(d) KidneyThis question was addressed to me in an interview for job.This intriguing question comes from Drugs Excretion in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
Which of the following will not be a limitation for prodrug design?(a) Formation of toxic product(b) An inert carrier can be cleaved off forming toxic product(c) Product cleaving off before reaching the target site(d) The cleaving of the carrier is also site-specificI had been asked this question during an interview for a job.I'm obligated to ask this question of Prodrugs topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve?(a) Drug excreted only by filtration(b) Drug filtered and actively reabsorbed(c) Drug filtered as well as actively secreted(d) Drug reabsorbed activelyThe question was posed to me in an online quiz.My doubt stems from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
Which of the following is not a physicochemical factor of drug that can affect the renal excretion?(a) Molecular size(b) Disintegration rate(c) pKa of the drug(d) Lipid solubilityThe question was asked in an online quiz.Question is taken from Drugs Excretion topic in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
The rate of urine flow influences the extent of reabsorption.(a) True(b) FalseI have been asked this question during an interview.My query is from Drugs Excretion in chapter Prodrugs & Excretion of Drugs of Drug Biotechnology
Which of the following is not a factor influencing pulmonary excretion?(a) Pulmonary blood flow(b) The solubility of volatile substance(c) Rate of respiration(d) Heart rateThis question was addressed to me in a national level competition.This question is from Drugs Excretion in section Prodrugs & Excretion of Drugs of Drug Biotechnology

Discussion

No Comment Found

Related InterviewSolutions

Reply to Comment