Which bond should be between the active drug and inert carrier?(a) Covalent bond(b) Vander Waal’s force(c) Di-sulphide bond(d) Ionic bondI got this question in an interview for job.I'm obligated to ask this question of Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology

Which bond should be between the active drug and inert carrier?(a) Cov

1.	Which bond should be between the active drug and inert carrier?(a) Covalent bond(b) Vander Waal’s force(c) Di-sulphide bond(d) Ionic bondI got this question in an interview for job.I'm obligated to ask this question of Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» The correct option is (a) Covalent bond Best EXPLANATION: This TYPE of prodrug where the active ingredient and inert drug is bonded by the covalent bond comes under carrier-linked prodrug. They are generally esters or amide. These drugs and modified their LIPOPHILICITY to a great EXTENT because of being attached to a carrier. The active drug is RELEASED by hydrolytic cleavage. The hydrolytic cleavage can be chemical or enzymatic.

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