Which of the following are the practical problems that arise due to the decrease in column diameter?(a) Requirement of large particle size and high pressure drop(b) Requirement of large particle size and low pressure drop(c) Requirement of small particle size and high pressure drop(d) Requirement of small particle size and low pressure dropI got this question in an international level competition.Question is from Liquid Chromatography in chapter Chromatography of Analytical Instrumentation

Which of the following are the practical problems that arise due to th

1.	Which of the following are the practical problems that arise due to the decrease in column diameter?(a) Requirement of large particle size and high pressure drop(b) Requirement of large particle size and low pressure drop(c) Requirement of small particle size and high pressure drop(d) Requirement of small particle size and low pressure dropI got this question in an international level competition.Question is from Liquid Chromatography in chapter Chromatography of Analytical Instrumentation
Answer» Right choice is (C) Requirement of small particle size and HIGH pressure drop The best EXPLANATION: The practical problems that arise due to a decrease in column diameter are the requirement of small particle size and high pressure drop. But, it increases column EFFICIENCY.

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