Which of the following drug is of Alkylamine class?(a) Mepyramine(b) Diphenhydramine(c) Cyclizine(d) ChlorphenamineThe question was posed to me in an interview for internship.Question is taken from Drug Concentration and Pharmacologic Response in chapter Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Which of the following drug is of Alkylamine class?(a) Mepyramine(b) D

1.	Which of the following drug is of Alkylamine class?(a) Mepyramine(b) Diphenhydramine(c) Cyclizine(d) ChlorphenamineThe question was posed to me in an interview for internship.Question is taken from Drug Concentration and Pharmacologic Response in chapter Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology
Answer» Correct choice is (d) Chlorphenamine Easy explanation: Ethylenediamine were the first group of clinically EFFECTIVE H1-antihistamines for example mepyramine. Diphenhydramine is of ETHANOLAMINE class. Chlorphenamine is of alkylamine class these drugs have FEWER sedative and GI adverse EFFECTS, but a greater INCIDENCE of CNS stimulation. Cyclizine is of piperazines class.

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