Which of the following histamine receptor increases the release of gastric acid?(a) H1 receptor(b) H2 receptor(c) H3 receptor(d) H4 receptorThis question was addressed to me in examination.My question is from Drug Concentration and Pharmacologic Response topic in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Which of the following histamine receptor increases the release of gas

1.	Which of the following histamine receptor increases the release of gastric acid?(a) H1 receptor(b) H2 receptor(c) H3 receptor(d) H4 receptorThis question was addressed to me in examination.My question is from Drug Concentration and Pharmacologic Response topic in section Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology
Answer» The correct option is (b) H2 receptor The best I can EXPLAIN: Found mainly in the gastric parietal cells, a low LEVEL of these cells can be found in vascular smooth muscles, NEUTROPHILS, CNS, heart, uterus. These are G protein-coupled receptor. Increases the release of gastric acid. H1 receptors mediate an increase in vascular PERMEABILITY at sites of inflammation induced by histamine.

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