Which of the following is incorrect about Hierarchical Clustering?(a) The tree-branching pattern illustrates a higher degree of relationship between related gene groups(b) It is not similar to the distance phylogenetic tree-building method(c) It produces a treelike structure that represents a hierarchy or relative relatedness of data groups(d) In the tree leaves, similar gene expression profiles are placed more closely together than dissimilar gene expression profilesI had been asked this question in exam.This interesting question is from Microarray-Based Approaches topic in section Functional Genomics & Proteomics of Bioinformatics

Which of the following is incorrect about Hierarchical Clustering?(a)

1.	Which of the following is incorrect about Hierarchical Clustering?(a) The tree-branching pattern illustrates a higher degree of relationship between related gene groups(b) It is not similar to the distance phylogenetic tree-building method(c) It produces a treelike structure that represents a hierarchy or relative relatedness of data groups(d) In the tree leaves, similar gene expression profiles are placed more closely together than dissimilar gene expression profilesI had been asked this question in exam.This interesting question is from Microarray-Based Approaches topic in section Functional Genomics & Proteomics of Bioinformatics
Answer» Correct ANSWER is (b) It is not similar to the DISTANCE phylogenetic tree-building method Explanation: A hierarchical clustering method is in PRINCIPLE similar to the distance phylogenetic tree-building method. When genes with similar expression profiles are grouped in such a way, functions for unknown genes can often be inferred. Hierarchical clustering uses the agglomerative approach that works in MUCH the same way as the UPGMA method, in which the most similar data pairs are joined FIRST to form a cluster.

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