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Which of the following is not an example of a drug undergoing acetylation reaction?(a) Hydrazine(b) Salicylic acids(c) Sulphonamides(d) HistaminesI got this question in an interview for internship.I want to ask this question from Drugs Biotransformation topic in portion Biotransformation of Drugs of Drug Biotechnology

Answer»

Right choice is (b) Salicylic acids

Easy explanation: Acetylation is an important METABOLIC PATHWAY for drugs containing primary amino GROUPS. Drugs which undergo acetylation reaction are histamine, sulphanilamide, and hydralazine. Acetylation may sometime LEAD to the production of toxic compounds.



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