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• Which of the following is not one of the training sets in SignalP?(a) Prokaryotes(b) Eukaryotes(c) Gram-positive bacteria(d) Gram-negative bacteriaThis question was posed to me in an interview for internship.I would like to ask this question from Protein Sorting topic in chapter Functional Genomics & Proteomics of Bioinformatics
• Only Advanced neural networks are used to discern long-distance pairwise interactions among cysteine residues.(a) True(b) FalseThis question was addressed to me during an interview.This intriguing question originated from Post translational Modification in division Functional Genomics & Proteomics of Bioinformatics
• A supervised analysis refers to classification of data into a set of predefined categories. For example, depending on the purpose of the experiment, the data can be classified into predefined ‘diseased’ or ‘normal’ categories.(a) True(b) FalseThe question was posed to me during an online exam.Enquiry is from Microarray-Based Approaches in section Functional Genomics & Proteomics of Bioinformatics
• Which of the following is incorrect about Classification of microarray data?(a) For microarray data, clustering analysis identifies coexpressed and coregulated genes(b) For microarray data, clustering analysis identifies coexpressed but not coregulated genes(c) For microarray data, clustering analysis identifies and coregulated but not coexpressed genes(d) Genes within a category have more similarity in expression than genes from different categories.I had been asked this question in an internship interview.I need to ask this question from Microarray-Based Approaches topic in division Functional Genomics & Proteomics of Bioinformatics
• Which of the following is incorrect about Data Collection?(a) The two-color microarray uses multiple dyes at times(b) The most common type of microarray protocol is the two-color microarray(c) The cDNAs are obtained by extracting total RNA or mRNA from tissues or cells and incorporating fluorescent dyes in the DNA strands during the cDNA biosynthesis(d) The expression of genes is measured via the signals from cDNAs hybridizing with the specific oligonucleotide probes on the microarrayI have been asked this question during an online interview.I'd like to ask this question from Microarray-Based Approaches in division Functional Genomics & Proteomics of Bioinformatics
• Which of the following is untrue regarding the classic yeast two-hybrid method?(a) Protein–protein interaction networks of yeast and a small number of other species have been subsequently determined using this method(b) This technique is a high throughput approach(c) Each bait and prey construct has to be prepared individually to map interactions between all proteins(d) It has been systematically applied to study interactions at the whole proteome levelI got this question in semester exam.This is a very interesting question from Protein Interactions topic in division Functional Genomics & Proteomics of Bioinformatics
• The signal sequences are typically _______ residues long, rich in _____ charged residues such as arginines as well as hydroxyl residues such as serines and threonines, but devoid of ______ charged residues.(a) 28 to 80, positively, negatively(b) 300 to 800, negatively, positively(c) 28 to 80, negatively, positively(d) 300 to 500, positively, negativelyI have been asked this question in an interview.My doubt stems from Protein Sorting in chapter Functional Genomics & Proteomics of Bioinformatics
• Which of the following is untrue regarding EST Index Construction?(a) The goal of the EST databases is to organize and consolidate the largely redundant EST data(b) The process includes a preprocessing step that removes masks repeats(c) There is no screening of vector contaminants(d) The goal of the EST databases is to improve the quality of the sequence information so the data can be used to extract full-length cDNAsThe question was posed to me during an interview.I want to ask this question from Sequence in portion Functional Genomics & Proteomics of Bioinformatics
• Which of the following is an incorrect statement about the terminologies related to protein sorting?(a) Subcellular localization is an integral part of protein functionality(b) Many proteins exhibit functions only after being transported to certain compartments of the cell(c) All the proteins exhibit functions after being transported to certain compartments of the cell(d) Protein sorting is also known as protein targetingI have been asked this question in an online interview.This is a very interesting question from Protein Sorting in section Functional Genomics & Proteomics of Bioinformatics
• SAGEmap is a SAGE database created by NCBI.(a) True(b) FalseI had been asked this question in an online interview.The origin of the question is Comparison of SAGE and DNA Microarrays in chapter Functional Genomics & Proteomics of Bioinformatics