Which of the following reduces the pain of injection?(a) If the drug precipitates(b) If the drug penetrates to the surrounding areas(c) If the solution is strongly acidic(d) More water-soluble drugThe question was asked at a job interview.The above asked question is from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Which of the following reduces the pain of injection?(a) If the drug p

1.	Which of the following reduces the pain of injection?(a) If the drug precipitates(b) If the drug penetrates to the surrounding areas(c) If the solution is strongly acidic(d) More water-soluble drugThe question was asked at a job interview.The above asked question is from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» RIGHT answer is (d) More water-soluble drug Explanation: Drug precipitation, penetration to SURROUNDING cells, strongly acidic, BASIC or alcohol makes it more painful after injection. Thus prodrugs are made to more water soluble. Making it more polar HELPS it to DIFFUSE easily to the plasma.

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