Which of the following wrong about HMM GENE?(a) It is also an HMM-based web program(b) It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features(c) HMM prediction is unbiased toward the locked region(d) If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regionsI got this question in an interview.The query is from Gene Prediction in Eukaryotes in division Gene and Promoter Prediction of Bioinformatics

Which of the following wrong about HMM GENE?(a) It is also an HMM-base

1.	Which of the following wrong about HMM GENE?(a) It is also an HMM-based web program(b) It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features(c) HMM prediction is unbiased toward the locked region(d) If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regionsI got this question in an interview.The query is from Gene Prediction in Eukaryotes in division Gene and Promoter Prediction of Bioinformatics
Answer» The CORRECT choice is (c) HMM prediction is unbiased toward the LOCKED region Best explanation: An HMM prediction is subsequently made with a bias toward the locked region and is extended from the locked region to predict the rest of the GENE CODING regions and even neighboring genes. The program is in a way a hybrid algorithm that uses both ab initio-based and homology-based CRITERIA.

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