Which of the given statements is incorrect about Clustering by single linkage?(a) In First step, a group of related sequences found in the all-against-all proteome comparison is subjected to a multiple sequence alignment usually by CLUSTALW(b) A neighbor-joining algorithm is rarely used in this method(c) This procedure and the algorithms are the same as those used to make a phylogenetic tree by the distance methods(d) A distance matrix that shows the number of amino acid changes between each pair of sequences is madeThis question was addressed to me at a job interview.My query is from Comparative Genomics topic in division Collecting & Storing Sequences in Laboratory of Bioinformatics

Which of the given statements is incorrect about Clustering by single

1.	Which of the given statements is incorrect about Clustering by single linkage?(a) In First step, a group of related sequences found in the all-against-all proteome comparison is subjected to a multiple sequence alignment usually by CLUSTALW(b) A neighbor-joining algorithm is rarely used in this method(c) This procedure and the algorithms are the same as those used to make a phylogenetic tree by the distance methods(d) A distance matrix that shows the number of amino acid changes between each pair of sequences is madeThis question was addressed to me at a job interview.My query is from Comparative Genomics topic in division Collecting & Storing Sequences in Laboratory of Bioinformatics
Answer» Correct CHOICE is (b) A neighbor-joining algorithm is rarely used in this method For explanation I would say: The matrix is then used to cluster the sequences by a neighbor-joining algorithm. These methods produce a tree or a different REPRESENTATION of the tree CALLED a dendrogram, which MINIMIZES the number of amino ACID changes that would generate the group of sequences.

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