Which of the given statements is incorrect about Cluster analysis?(a) Clustering organizes the proteins into groups by some objective criterion(b) One criterion for a matching protein pair is the statistical significance of their alignment score(c) The P or E value from BLAST searches cannot be the criterion for a matching protein pair(d) A criterion for clustering proteins is the distance between each pair of sequences in a multiple sequence alignmentThe question was posed to me in semester exam.The query is from Comparative Genomics in section Collecting & Storing Sequences in Laboratory of Bioinformatics

Which of the given statements is incorrect about Cluster analysis?(a)

1.	Which of the given statements is incorrect about Cluster analysis?(a) Clustering organizes the proteins into groups by some objective criterion(b) One criterion for a matching protein pair is the statistical significance of their alignment score(c) The P or E value from BLAST searches cannot be the criterion for a matching protein pair(d) A criterion for clustering proteins is the distance between each pair of sequences in a multiple sequence alignmentThe question was posed to me in semester exam.The query is from Comparative Genomics in section Collecting & Storing Sequences in Laboratory of Bioinformatics
Answer» CORRECT choice is (c) The P or E VALUE from BLAST searches cannot be the criterion for a matching protein pair The explanation is: Option c and b mean the same YET are different by the negation in option c.The LOWER this value, the better the alignment. There will be a cutoff P or E value at which the matches in the BLAST search are no longer considered significant. A value of P or E = 0.01–0.05 is usually the POINT at which the alignment score is no longer considered to be significant inorder to focus on a more closely related group of proteins.

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