1.

Which one is the correct equation to calculate the fraction of unbound drug in plasma?(a) Concentration of unbound drug in plasma / total plasma concentration of drug(b) Total plasma concentration of drug / Concentration of unbound drug in plasma(c) 1/Concentration of unbound drug in plasma(d) 1/total plasma concentration of drugI had been asked this question in a job interview.The question is from Drugs Excretion in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Answer» RIGHT choice is (a) Concentration of UNBOUND DRUG in plasma / total plasma concentration of drug

Best explanation: The fraction of drug bound to plasma PROTEINS can be calculated by the equation fu = Cu/C. Here fu is fraction of unbound drug and Cu is the concentration of unbound drug in plasma and C is the total plasma concentration of the drug.


Discussion

No Comment Found

Related InterviewSolutions