Which one of the following is a critical rate-limiting step of drug absorption?(a) Rate of drug disintegration(b) Size of the drug(c) Size of the porous particle(d) Rate of dissolutionThe question was posed to me during an interview for a job.Query is from Physicochemical Factors Affecting Drug Absorption in portion Absorption of Drugs of Drug Biotechnology

Which one of the following is a critical rate-limiting step of drug ab

1.	Which one of the following is a critical rate-limiting step of drug absorption?(a) Rate of drug disintegration(b) Size of the drug(c) Size of the porous particle(d) Rate of dissolutionThe question was posed to me during an interview for a job.Query is from Physicochemical Factors Affecting Drug Absorption in portion Absorption of Drugs of Drug Biotechnology
Answer» Right option is (d) Rate of dissolution To explain I would say: For ORALLY ADMINISTERED drug, the two critically slower rate determining step is the rate of dissolution and the rate of drug PERMEATION. Dissolution is the rate determining stem for poorly aqueous SOLUBLE drugs and hydrophobic drugs.

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