Which one of the following will be an example of changing the physical form of the drug to get a prodrug?(a) Ethyl mercaptan to 1,3-Diesters(b) Trichloroethanol to p-Acetamidobenzene ester(c) Ethyl mercaptan to phthalate esters(d) Chloramphenicol to palmitate esterI have been asked this question in examination.My doubt is from Prodrugs topic in section Prodrugs & Excretion of Drugs of Drug Biotechnology

Which one of the following will be an example of changing the physical

1.	Which one of the following will be an example of changing the physical form of the drug to get a prodrug?(a) Ethyl mercaptan to 1,3-Diesters(b) Trichloroethanol to p-Acetamidobenzene ester(c) Ethyl mercaptan to phthalate esters(d) Chloramphenicol to palmitate esterI have been asked this question in examination.My doubt is from Prodrugs topic in section Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» CORRECT option is (a) Ethyl mercaptan to 1,3-Diesters Easiest explanation: Ethyl mercaptan to 1,3-Diesters involves the formation of symmetrical molecules having the tendency to form crystals. Trichloroethanol to p-Acetamidobenzene ester is not the correct form, here Trichloroethanol should be CONVERTED to p-Acetamidobenzoic acid ester. Ethyl mercaptan to PHTHALATE esters is DONE for the improvement of odour and CHLORAMPHENICOL to palmitate ester is done for the improvement of odour.

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