Why carbenicillin cannot be given orally?(a) Tastes bad(b) Bad odour(c) Degraded by saliva(d) Hydrolysed easilyThe question was asked at a job interview.Origin of the question is Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology

Why carbenicillin cannot be given orally?(a) Tastes bad(b) Bad odour(c

1.	Why carbenicillin cannot be given orally?(a) Tastes bad(b) Bad odour(c) Degraded by saliva(d) Hydrolysed easilyThe question was asked at a job interview.Origin of the question is Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» The CORRECT answer is (d) Hydrolysed easily The explanation is: Carbenicillin, broad-spectrum penicillin, gets hydrolyzed very easily. Thus if given orally it will be a REACTION with ACID in the stomach. Thus these are MADE into ester prodrugs which are stable at gastric pH and above 7.

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Why carbenicillin cannot be given orally?(a) Tastes bad(b) Bad odour(c) Degraded by saliva(d) Hydrolysed easilyThe question was asked at a job interview.Origin of the question is Prodrugs in section Prodrugs & Excretion of Drugs of Drug Biotechnology

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