Why lipophilic drugs are absorbed easily?(a) Less hydrolysed(b) Favours passive diffusion(c) Dissolution rate high(d) Can easily merge with the cell membraneI had been asked this question at a job interview.This is a very interesting question from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology

Why lipophilic drugs are absorbed easily?(a) Less hydrolysed(b) Favour

1.	Why lipophilic drugs are absorbed easily?(a) Less hydrolysed(b) Favours passive diffusion(c) Dissolution rate high(d) Can easily merge with the cell membraneI had been asked this question at a job interview.This is a very interesting question from Prodrugs topic in division Prodrugs & Excretion of Drugs of Drug Biotechnology
Answer» The CORRECT option is (b) FAVOURS passive DIFFUSION To elaborate: Lipophilic drugs has high membrane-water partition coefficient thus it favours passive diffusion. These are more lipophilic, better absorbed and rapidly hydrolysed to the parent DRUG in BLOOD.

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