Within-Genome Approach is to identify regions within a genome with unusual compositions.(a) True(b) FalseI had been asked this question in a job interview.My question comes from Comparative Genomics topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics

Within-Genome Approach is to identify regions within a genome with unu

1.	Within-Genome Approach is to identify regions within a genome with unusual compositions.(a) True(b) FalseI had been asked this question in a job interview.My question comes from Comparative Genomics topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Right answer is (a) True For explanation: Single or oligonucleotide STATISTICS, such as G–C composition, codon BIAS, and oligonucleotide frequencies are used. Unusual nucleotide statistics in certain genomic REGIONS versus the rest of the genome may help to identify “foreign” genes in a genome. A commonly used parameter is GC skew ((G − C)/(G + C)), which is compositional bias for G in a DNA sequence and is a commonly used indicator for newly acquired GENETIC elements.

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