The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.(a) True(b) FalseThe question was asked by my school teacher while I was bunking the class.I'd like to ask this question from Genome Sequencing in portion Genome Mapping, Assembly and Comparison of Bioinformatics

The whole genome shotgun approach can produce a draft sequence very ra

1.	The whole genome shotgun approach can produce a draft sequence very rapidly because it is based on the direct sequencing approach.(a) True(b) FalseThe question was asked by my school teacher while I was bunking the class.I'd like to ask this question from Genome Sequencing in portion Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Right option is (a) True To explain: HOWEVER, it is computationally very demanding to assemble the SHORT random fragments. Although the approach has been successfully employed in SEQUENCING small microbial genomes, for a complex EUKARYOTIC genome that contains high levels of repetitive sequences, such as the human genome, the full shotgun approach becomes less accurate and tends to leave more “holes” in the final assembled sequence than the hierarchical approach. Current genome sequencing of large organisms often USES a combination of both approaches.

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