100 + Interview Questions in Biosignalling in Biochemistry Page 2 InterviewSolution

51.	Acetylcholine receptor ion channel is an example of _____________(a) Gated ion channel(b) Receptor enzymes(c) Membrane protein(d) Nuclear proteinI had been asked this question in my homework.This interesting question is from Molecular Mechanisms of Signal Transduction in portion Biosignalling of Biochemistry
Answer» Correct option is (a) GATED ion CHANNEL To explain I would say: ACETYLCHOLINE receptor ion channel is an example of gated ion channel.

Discussion

52.	Programmed cell death is termed as ___________(a) Metastasis(b) Apoptosis(c) Proliferation(d) Mitotic terminationThis question was posed to me in a national level competition.This interesting question is from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in chapter Biosignalling of Biochemistry
Answer» The CORRECT ANSWER is (B) Apoptosis Explanation: Apoptosis can also be TERMED as programmed cell death.

Discussion

53.	How does Ras oncogene contribute to cancers?(a) It codes for an anti-apoptotic protein, produced in abnormally large amounts(b) It codes for a GTPase switch protein, which in its mutated form cannot be switched off(c) It codes for a transcription factor produced abnormally in large amounts(d) A growth factor that is continually active is encoded in its truncated formThe question was asked by my school principal while I was bunking the class.This interesting question is from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death topic in portion Biosignalling of Biochemistry
Answer» Right CHOICE is (b) It CODES for a GTPase switch protein, which in its mutated FORM cannot be SWITCHED off The best explanation: Ras oncogene codes for a GTPase switch protein, which in its mutated form cannot be switched off.

Discussion

54.	Which of the following statements is not true about olfactory neurons?(a) Axons of olfactory neurons combine to form olfactory nerves(b) They synapse with cells in olfactory bulb(c) They have receptors that react with odorants dissolved in fluid(d) They are uni-polar neuronsThe question was posed to me in an online quiz.I want to ask this question from Sensory Transduction in Vision, Olfaction and Gustation in division Biosignalling of Biochemistry
Answer» CORRECT answer is (d) They are uni-polar NEURONS The EXPLANATION: OLFACTORY neurons are bipolar neurons.

Discussion

55.	Autophosphorylation is done on _________(a) His residues(b) Ser/Thr residues(c) Cys residues(d) Lys residuesI had been asked this question during an online interview.This is a very interesting question from Signaling in Microorganisms and Plants in portion Biosignalling of Biochemistry
Answer» CORRECT option is (b) Ser/Thr RESIDUES Explanation: AUTOPHOSPHORYLATION is done on Ser/Thr residues.

Discussion

56.	Which out of the following is not a neurotransmitter?(a) Noadrenaline(b) Cyclic AMP(c) Dopamine(d) Acetyl cholineThe question was asked in final exam.My question is taken from Gated Ion Channels topic in division Biosignalling of Biochemistry
Answer» RIGHT choice is (b) CYCLIC AMP Explanation: Cyclic AMP is a secondary MESSENGER molecule controlled by hormones and neurotransmitters.

Discussion

57.	Oncogenes do not encode for ___________(a) Trans-membrane protein receptors(b) Growth factors(c) DNA-dependent RNA polymerase(d) Cytoplasmic G-proteins and protein kinasesI had been asked this question in my homework.My doubt is from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in portion Biosignalling of Biochemistry
Answer» The CORRECT choice is (c) DNA-dependent RNA POLYMERASE Easiest explanation: Oncogenes encode for RNA-dependent DNA polymerase.

Discussion

58.	Which drug is used to terminate early pregnancies?(a) RU486(b) Metformin(c) Glucophage(d) VictozaI got this question during an internship interview.I need to ask this question from Regulation of Transcription by Steroid Hormones in chapter Biosignalling of Biochemistry
Answer» Correct choice is (a) RU486 Easy EXPLANATION: METFORMIN, Glucophage and VICTOZA are the drugs to cure DIABETES.

Discussion

59.	Cdk2/cyclinE functions in ____________(a) G2/M transition(b) G2(c) M(d) G1/S transitionI got this question by my college professor while I was bunking the class.The query is from Regulation of the Cell Cycle by Protein Kinases topic in division Biosignalling of Biochemistry
Answer» The CORRECT OPTION is (d) G1/S transition Explanation: Cdk1/cyclinB FUNCTIONS in M PHASE Cdk2/cyclinA functions in S phase, G2 phase.

Discussion

60.	Which of the following is not responsible of producing diarrhea?(a) Elevation in [cGMP](b) Increase in Cl^– secretion(c) Decrease in reabsorption of water by the intestinal epithelium(d) Decrease in Cl^– secretionI had been asked this question in an interview for job.My doubt is from Receptor Enzymes in section Biosignalling of Biochemistry
Answer» Right option is (d) Decrease in Cl^– SECRETION To ELABORATE: ELEVATION in [CGMP] leads to increase in Cl^– secretion and decrease in reabsorption of water by the intestinal epithelium.

Discussion

61.	Insulin receptor is an example of _____________(a) Steroid receptors(b) Serpentine receptors(c) Adhesion receptors(d) Receptor enzymesThis question was addressed to me in semester exam.This interesting question is from Molecular Mechanisms of Signal Transduction topic in chapter Biosignalling of Biochemistry
Answer» The correct choice is (d) RECEPTOR enzymes To elaborate: INSULIN receptor is nuclear receptor.

Discussion

62.	Protein kinase ERK is activated by phosphorylation of ____________(a) Only Thr(b) Only Tyr(c) Both Thr and Tyr(d) Only SerThis question was posed to me in unit test.This key question is from Receptor Enzymes topic in chapter Biosignalling of Biochemistry
Answer» Right choice is (C) Both Thr and TYR The best EXPLANATION: Both Thr and Tyr are phosphorylated to activate the protein KINASE ERK.

Discussion

63.	Which of the following is false about phosphorylation by IRS on serine residue?(a) It is an inhibitory phosphorylation(b) It is molecular mechanism for insulin resistance(c) It increases insulin levels(d) Target tissues fail to respond to circulating insulinThis question was posed to me by my school principal while I was bunking the class.Question is from Receptor Enzymes topic in chapter Biosignalling of Biochemistry
Answer» Correct choice is (c) It increases insulin levels Best explanation: Inhibitory serine phosphorylation is a MOLECULAR MECHANISM for insulin resistance which is a condition where target TISSUES fail to respond to circulating insulin.

Discussion

64.	Which of the following is not a downstream component?(a) Ras(b) MEK(c) ERK(d) PIP3I had been asked this question in a national level competition.This intriguing question comes from Multivalent Scaffold Proteins and Membrane Rafts in division Biosignalling of Biochemistry
Answer» RIGHT CHOICE is (d) PIP3 Best explanation: RAS, MEK and ERK are the DOWNSTREAM components.

Discussion

65.	GPCR is comprised of ___________(a) 7 transmembrane helices(b) 8 transmembrane helices(c) 9 transmembrane helices(d) 10 transmembrane helicesI have been asked this question in exam.My query is from G Protein in division Biosignalling of Biochemistry
Answer» The correct CHOICE is (a) 7 transmembrane helices The EXPLANATION: GPCRS are 7 transmembrane DOMAIN RECEPTORS.

Discussion

66.	Protein kinase A is ____________(a) Completely inhibited by cyclic AMP(b) Allosterically activated by cyclic AMP(c) Affected by cyclic AMP only under unusual circumstances(d) Activated by covalent binding of cyclic AMPThis question was addressed to me in a job interview.The doubt is from G Protein in portion Biosignalling of Biochemistry
Answer» Right choice is (b) ALLOSTERICALLY activated by cyclic AMP The EXPLANATION: Protein kinase A is activated when CAMP allosterically BINDS to a REGULATORY peptide.

Discussion

67.	Ras protein is a ____________(a) G-protein switch(b) Small monomeric GTPase switch protein(c) Serine-threonine kinase(d) Tyrosine kinaseThe question was asked by my school teacher while I was bunking the class.My question is based upon Receptor Enzymes in chapter Biosignalling of Biochemistry
Answer» Correct ANSWER is (b) Small monomeric GTPASE SWITCH protein Easy explanation: Ras protein is a small monomeric GTPase switch protein, involved in TRANSMITTING SIGNALS within cells.

Discussion

68.	Which of the following statements about action potential is false?(a) Na^+/K^+ pumps are directly involved in creating the action potential(b) Na^+ and K^+ concentrations are not significantly changed during an action potential(c) This includes both positive and negative feedback loops(d) Only a relatively small number of Na^+ and K^+ actually diffuse across the membraneI have been asked this question in an online interview.My question comes from Gated Ion Channels in division Biosignalling of Biochemistry
Answer» RIGHT answer is (B) Na^+ and K^+ CONCENTRATIONS are not significantly CHANGED during an action potential Explanation: The concentration of K^+ is higher inside and concentration of Na^+ is more OUTSIDE.

Discussion

69.	Which property of p53 enables it to prevent the development of cancer?(a) It is a transcription factor that causes protein production which stimulates the cell cycle(b) It prevents replication of cells with damaged DNA(c) It prevents cells from triggering apoptosis(d) It stimulates synthesis of DNA repair enzymes that replace telomere sequence lost during cell divisionI had been asked this question during an internship interview.I'm obligated to ask this question of Oncogenes, Tumor Suppressor Genes and Programmed Cell Death topic in chapter Biosignalling of Biochemistry
Answer» Right answer is (b) It prevents replication of CELLS with damaged DNA To EXPLAIN I would say: P53 prevents replication of cells with damaged DNA.

Discussion

70.	Which of the following could be coded by a tumor-supressor gene?(a) A protein that helps prevent progression through cell cycle(b) A protein that helps prevent apoptosis(c) A protein that codes for a DNA repair enzyme(d) A protein that forms part of a growth factor signaling pathwayI had been asked this question in unit test.Question is taken from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in portion Biosignalling of Biochemistry
Answer» The CORRECT choice is (a) A protein that HELPS prevent progression through cell CYCLE Explanation: A protein that helps prevent progression through cell cycle could be CODED by a tumor-supressor GENE.

Discussion

71.	Vision, olfaction and gustation employ _________(a) Serpentine receptors(b) Enzyme coupled receptors(c) Ligand gated receptors(d) Adhesion receptorsThe question was asked at a job interview.Query is from Sensory Transduction in Vision, Olfaction and Gustation in section Biosignalling of Biochemistry
Answer» RIGHT option is (a) Serpentine receptors The EXPLANATION: Serpentine receptors PLAY an IMPORTANT role in rhodopsins, visual sense, OLFACTION and gustation.

Discussion

72.	Which of the following statements about Arabidopsis is not true?(a) In Arabidopsis, CTR-1 Ser/Thr protein kinase is activated by ethylene(b) Activation of MAPK cascade(c) EINI activation(d) Synthesis of ERF1 transcription factorThis question was addressed to me in class test.Origin of the question is Signaling in Microorganisms and Plants topic in division Biosignalling of Biochemistry
Answer» The CORRECT choice is (a) In Arabidopsis, CTR-1 Ser/Thr protein KINASE is ACTIVATED by ethylene Best EXPLANATION: In Arabidopsis, CTR-1 Ser/Thr protein kinase is inactivated by ethylene.

Discussion

73.	How many types of signal transducers are there?(a) 3(b) 4(c) 5(d) 6This question was addressed to me during a job interview.This interesting question is from Molecular Mechanisms of Signal Transduction in chapter Biosignalling of Biochemistry
Answer» Right ANSWER is (d) 6 Explanation: Gated ion channels, receptor enzymes, membrane PROTEINS that ACT through G protein, nuclear proteins, membrane proteins and adhesion receptors are the 6 types of signal transducers.

Discussion

74.	Number of affected molecules increases geometrically in an enzyme cascade in _____________(a) Specificity(b) Amplification(c) Adaptation(d) IntegrationThis question was posed to me during an internship interview.This is a very interesting question from Molecular Mechanisms of Signal Transduction topic in portion Biosignalling of Biochemistry
Answer» The correct option is (b) Amplification To EXPLAIN: Signal molecule fits its binding site on its complementary RECEPTOR called as specificity. Receptor is removed from cell SURFACE in adaptation. A regulatory OUTCOME result from INTEGRATED input from both receptors is in integration.

Discussion

75.	Passage of a cell through stages of cell cycle is controlled by a protein kinase that phosphorylates many different proteins at appropriate times.(a) Cdk activating kinase(b) Cyclin-dependent kinase(c) Cyclins(d) Tyrosine kinaseThe question was asked at a job interview.This intriguing question comes from Regulation of the Cell Cycle by Protein Kinases topic in chapter Biosignalling of Biochemistry
Answer» The correct CHOICE is (B) Cyclin-dependent kinase Explanation: PASSAGE of a cell through stages of cell CYCLE is CONTROLLED by Cdk.

Discussion

76.	Which out of the following statements is true about gene regulation in bacteria?(a) Repressor protein blocks transcription by binding to operator sequence(b) Activator proteins bind near promoters and increase the efficiency of transcription(c) Enhancers commonly regulate transcription(d) Genes with related functions are often grouped together and have a single start codonThe question was posed to me in an interview for job.My question is taken from Regulation of Transcription by Steroid Hormones topic in division Biosignalling of Biochemistry
Answer» CORRECT CHOICE is (a) Repressor protein blocks transcription by binding to operator sequence The BEST explanation: A repressor binds at operator element and REGULATES transcription NEGATIVELY.

Discussion

77.	Cholera toxin is not a/an _________(a) Enzyme inhibitor(b) Enzyme activator(c) Enzyme modifier(d) Toxin released from bacteria in the infected intestineI have been asked this question by my college professor while I was bunking the class.Asked question is from Sensory Transduction in Vision, Olfaction and Gustation in section Biosignalling of Biochemistry
Answer» The correct option is (B) Enzyme activator To elaborate: Cholera TOXIN is released from BACTERIA in the infected INTESTINE. It inhibits the stimulation of cAMP SYNTHESIS.

Discussion

78.	Which of the following directly phosphorylate tyrosines to start a kinase protein enzymatic cascade?(a) Receptor tyrosine kinase(b) Receptor guanylyl cyclases(c) Receptor serine kinase(d) Receptor threonine kinaseI had been asked this question in class test.The origin of the question is Multivalent Scaffold Proteins and Membrane Rafts topic in portion Biosignalling of Biochemistry
Answer» Correct option is (a) RECEPTOR TYROSINE KINASE The best I can explain: Only receptor tyrosine kinase directly phosphorylates tyrosine to start a kinase protein enzymatic CASCADE.

Discussion

79.	Which of the following is not a G-protein coupled receptor?(a) Glycine receptor(b) Adrenergic receptor(c) Glutamate receptor(d) Muscarinic receptorI had been asked this question during an interview.I'd like to ask this question from G Protein topic in section Biosignalling of Biochemistry
Answer» CORRECT choice is (a) GLYCINE RECEPTOR The EXPLANATION: Glycine receptor is a neurotransmitter but not a GPCR.

Discussion

80.	Depolarization and repolarization changes that occur during the action potential are produced by ____________(a) Negative feedback loops(b) Carrier mediated transport(c) Simple diffusion of ions down their concentration gradient(d) Active transport pumps along the neuron membraneThe question was posed to me in final exam.The question is from Gated Ion Channels topic in division Biosignalling of Biochemistry
Answer» The correct OPTION is (d) Active transport pumps along the neuron membrane Easy EXPLANATION: NA^+ channels open at the beginning of action potential and moves into the axon causing depolarization, when K^+ channels open REPOLARIZATION TAKES place and moves out of the axon.

Discussion

81.	Signal molecule fits the binding site on its complementary receptor called as _____________(a) Specificity(b) Amplification(c) Integration(d) CooperativityI have been asked this question in an online quiz.My enquiry is from Molecular Mechanisms of Signal Transduction in division Biosignalling of Biochemistry
Answer» Right ANSWER is (a) Specificity Explanation: NUMBER of AFFECTED molecules increases geometrically in an ENZYME cascade in amplification. A regulatory outcome result from integrated INPUT from both receptors is in integration.

Discussion

82.	Objects are perceived by photo receptors because rods or cones(a) Depolarize(b) Hyperpolarize(c) Repolarize(d) PolarizeThe question was posed to me during an interview.This interesting question is from Sensory Transduction in Vision, Olfaction and Gustation topic in chapter Biosignalling of Biochemistry
Answer» The correct choice is (b) Hyperpolarize To EXPLAIN: The objects are perceived by photo RECEPTORS because rods or cones hyperpolarize as their PIGMENTS may decompose in presence of light.

Discussion

83.	Which out of the following is not involved in signal transduction by β-adrenergic receptor pathway?(a) GTP(b) ATP(c) cAMP(d) cGMPI have been asked this question in an interview.Asked question is from G Protein topic in portion Biosignalling of Biochemistry
Answer» Right answer is (c) cAMP For explanation: cAMP is not INVOLVED in SIGNAL TRANSDUCTION by β-adrenergic RECEPTOR PATHWAY.

Discussion

84.	SH2 domain specifically binds to _____________(a) GDP(b) Ca^+2(c) Phosphorylated tyrosine residues(d) Phosphorylated serine residuesThe question was asked in an interview.I want to ask this question from Receptor Enzymes topic in portion Biosignalling of Biochemistry
Answer» RIGHT OPTION is (c) Phosphorylated tyrosine residues To ELABORATE: Phosphorylated tyrosine residues SPECIFICALLY binds SH2 domain during signal transduction.

Discussion

85.	Which of the following statements is true about transmembrane electrical potential?(a) The chemical gradient drives Cl^– and K^+ inwards(b) The electrical gradient drives Na^+ and Ca^+2 inwards(c) The chemical gradient drives Na^+ and Ca^+2 inwards and K^+ outward(d) The chemical gradient drives Cl^– and K^+ outwardsThis question was posed to me in unit test.My question is from Gated Ion Channels in section Biosignalling of Biochemistry
Answer» Right option is (c) The chemical gradient DRIVES Na^+ and Ca^+2 inwards and K^+ OUTWARD The explanation is: The chemical gradient drives Na^+ and Ca^+2 inwards and K^+ outward, electrical gradient drives Cl^–.

Discussion

86.	Migration of cancerous cells from the site of origin to other part of the body forming secondary tumors is called ___________(a) Diapedesis(b) Metastasis(c) Proliferation(d) ApoptosisI have been asked this question during an interview for a job.My question is from Oncogenes, Tumor Suppressor Genes and Programmed Cell Death in section Biosignalling of Biochemistry
Answer» CORRECT answer is (b) METASTASIS To explain: Metastasis can be defined as MIGRATION of cancerous CELLS from the site of origin to other part of the body forming secondary TUMORS.

Discussion

87.	When visual stimulus reaches receptors in retina of eye, first process involving absorption of physical energy by receptors is?(a) Reception(b) Transduction(c) Coding(d) AdaptationThe question was posed to me in semester exam.The above asked question is from Sensory Transduction in Vision, Olfaction and Gustation in chapter Biosignalling of Biochemistry
Answer» Correct option is (a) RECEPTION The best EXPLANATION: Reception is the first process involved in the absorption of physical energy by receptors when visual STIMULUS reaches receptors in retina of eye.

Discussion

88.	Diffusion of K^+ out of the cell makes the inside of it less positive, or more negative and acts to restore the original resting membrane potential. This process is called ____________(a) Repolarization(b) Depolarization(c) Hyperpolarization(d) OvershootI had been asked this question by my college professor while I was bunking the class.This question is from Gated Ion Channels topic in section Biosignalling of Biochemistry
Answer» Right ANSWER is (a) REPOLARIZATION The explanation is: DIFFUSION of K^+ out of the CELL makes the inside of it less positive, or more negative and acts to restore the original resting membrane potential. This PROCESS is called repolarization.

Discussion

89.	Receptor proteins that indirectly activate enzymes that generate intracellular second messengers are _____________(a) Steroid receptors(b) Serpentine receptors(c) Adhesion receptors(d) Receptor enzymesThis question was posed to me in exam.I need to ask this question from Molecular Mechanisms of Signal Transduction topic in division Biosignalling of Biochemistry
Answer» Right option is (b) SERPENTINE receptors For EXPLANATION: Receptor PROTEINS that indirectly activate enzymes that generate intracellular SECOND MESSENGERS are serpentine receptors.

Discussion

90.	The information which is represented by a signal is detected by specific receptors and converted to a cellular response; this conversion is called _____________(a) Signal amplification(b) Signal transversion(c) Signal transduction(d) Signal integrationThis question was addressed to me in an interview for job.The doubt is from Molecular Mechanisms of Signal Transduction in portion Biosignalling of Biochemistry
Answer» Right choice is (c) Signal TRANSDUCTION To explain I would say: The information which is represented by a signal is detected by SPECIFIC receptors and CONVERTED to a cellular RESPONSE; this conversion is called signal transduction.

Discussion

91.	Negative regulator of ethylene response is _________(a) LPS(b) CTR1(c) BAK1(d) MAPKI have been asked this question during an interview for a job.This interesting question is from Signaling in Microorganisms and Plants in section Biosignalling of Biochemistry
Answer» The correct OPTION is (B) CTR1 The explanation: CTR1 is the NEGATIVE regulator of ethylene RESPONSE.

Discussion

92.	Which of the following are stimulated to become membrane associated upon binding of insulin to the insulin receptor?(a) PH-domain(b) PTB(c) SH3(d) SH2I got this question at a job interview.This key question is from Multivalent Scaffold Proteins and Membrane Rafts topic in portion Biosignalling of Biochemistry
Answer» CORRECT answer is (a) PH-DOMAIN Explanation: PH domain is stimulated to BECOME membrane ASSOCIATED UPON binding of insulin to the insulin receptor.

Discussion

93.	cGMP-dependent protein kinase is also called ____________(a) Protein kinase B(b) Protein kinase A(c) Protein kinase G(d) Protein kinase CI have been asked this question by my college director while I was bunking the class.I need to ask this question from Receptor Enzymes topic in section Biosignalling of Biochemistry
Answer» RIGHT choice is (C) PROTEIN KINASE G To elaborate: cGMP-dependent protein kinase is also CALLED protein kinase G.

Discussion

94.	Activation of guanylyl cyclase produces ____________(a) Guanosine 3’, 5’-cyclic monophosphate(b) Guanosine 2’, 5’-cyclic monophosphate(c) Guanosine 4’, 5’-cyclic monophosphate(d) Guanosine 1’, 5’-cyclic monophosphateThe question was asked in an interview.The doubt is from Receptor Enzymes in portion Biosignalling of Biochemistry
Answer» The CORRECT option is (a) Guanosine 3’, 5’-cyclic monophosphate Best explanation: Guanosine 3’, 5’-cyclic monophosphate is produced by the activation of guanylyl cyclase.

Discussion

95.	cAMP and cGMP are derived from ____________(a) ATP and GTP by the actions of guanylate cyclase and adenylate cyclase respectively(b) ATP and GTP by the actions of adenylate cyclase and gualnlate cyclase respectively(c) GTP and ATP by the actions of adenylate cyclase and guanylate cyclase respectively(d) None of the mentionedI have been asked this question in final exam.This intriguing question originated from Receptor Enzymes in division Biosignalling of Biochemistry
Answer» Right ANSWER is (b) ATP and GTP by the actions of adenylate CYCLASE and gualnlate cyclase respectively For EXPLANATION: cGMP is DERIVED from GTP by the actions of guanylate cyclase and cAMP is derived from ATP by the actions ofadenylate cyclase respectively.

Discussion

96.	Which of the following are intracellular second messengers?(a) Acetylcholine(b) Glycine(c) IP3(d) GlutamateI have been asked this question in an interview for internship.This interesting question is from Gated Ion Channels topic in portion Biosignalling of Biochemistry
Answer» Right choice is (C) IP3 Best explanation: INOSITOL TRIPHOSPHATE together with diacylgycerol is a secondary messenger used in signal transduction and lipid SIGNALING in cells.

Discussion

97.	Cyclin dependent kinases which control progression through cell cycle checkpoints are totally activated by which of the following?(a) Binding to cyclin, plus phosphorylation by a Cdk activating protein kinase(b) Binding to cyclins(c) Phosphorylation by Cdk activating protein kinase(d) Phosphorylation by a tyrosine kinaseI had been asked this question in an interview for internship.This intriguing question comes from Regulation of the Cell Cycle by Protein Kinases in section Biosignalling of Biochemistry
Answer» Right choice is (a) BINDING to cyclin, PLUS phosphorylation by a Cdk ACTIVATING protein kinase Explanation: Cyclin DEPENDENT KINASES are totally activated by binding to cyclin and phosphorylation by a Cdk activating protein kinase.

Discussion

98.	In which phase of cell cycle is DNA replicated?(a) G1 phase(b) S phase(c) G2 phase(d) M phaseThis question was addressed to me in semester exam.Question is taken from Regulation of the Cell Cycle by Protein Kinases topic in portion Biosignalling of Biochemistry
Answer» Right option is (B) S PHASE To EXPLAIN: During the S phase, DNA replication TAKES place.

Discussion

99.	The 2-component system drives bacterial chemotaxis by coupling autophosphoryaltion of which receptor to phosphorylation of respective regulatory protein?(a) His kinase(b) Adenylyl cyclase(c) Guanylyl cyclase(d) NoneThis question was posed to me in an internship interview.My doubt is from Signaling in Microorganisms and Plants topic in portion Biosignalling of Biochemistry
Answer» Right ANSWER is (a) His kinase For explanation I would say: The 2-component SYSTEM DRIVES bacterial chemotaxis by coupling auto-phosphorylation of his kinase to phosphorylation of the respective regulatory protein.

Discussion

100.	Which of the following is involved in proline rich motif binding?(a) SH2(b) SH3(c) PTB(d) PHI have been asked this question in an interview for job.The above asked question is from Multivalent Scaffold Proteins and Membrane Rafts topic in section Biosignalling of Biochemistry
Answer» The correct CHOICE is (b) SH3 For explanation I would SAY: SH2 is involved in phospho-tyrosine BINDING.

Discussion

Explore topic-wise InterviewSolutions in .

Autophosphorylation is done on _________(a) His residues(b) Ser/Thr residues(c) Cys residues(d) Lys residuesI had been asked this question during an online interview.This is a very interesting question from Signaling in Microorganisms and Plants in portion Biosignalling of Biochemistry

Which out of the following is not a neurotransmitter?(a) Noadrenaline(b) Cyclic AMP(c) Dopamine(d) Acetyl cholineThe question was asked in final exam.My question is taken from Gated Ion Channels topic in division Biosignalling of Biochemistry

Which drug is used to terminate early pregnancies?(a) RU486(b) Metformin(c) Glucophage(d) VictozaI got this question during an internship interview.I need to ask this question from Regulation of Transcription by Steroid Hormones in chapter Biosignalling of Biochemistry

Cdk2/cyclinE functions in ____________(a) G2/M transition(b) G2(c) M(d) G1/S transitionI got this question by my college professor while I was bunking the class.The query is from Regulation of the Cell Cycle by Protein Kinases topic in division Biosignalling of Biochemistry

Protein kinase ERK is activated by phosphorylation of ____________(a) Only Thr(b) Only Tyr(c) Both Thr and Tyr(d) Only SerThis question was posed to me in unit test.This key question is from Receptor Enzymes topic in chapter Biosignalling of Biochemistry

Which of the following is not a downstream component?(a) Ras(b) MEK(c) ERK(d) PIP3I had been asked this question in a national level competition.This intriguing question comes from Multivalent Scaffold Proteins and Membrane Rafts in division Biosignalling of Biochemistry

GPCR is comprised of ___________(a) 7 transmembrane helices(b) 8 transmembrane helices(c) 9 transmembrane helices(d) 10 transmembrane helicesI have been asked this question in exam.My query is from G Protein in division Biosignalling of Biochemistry

Ras protein is a ____________(a) G-protein switch(b) Small monomeric GTPase switch protein(c) Serine-threonine kinase(d) Tyrosine kinaseThe question was asked by my school teacher while I was bunking the class.My question is based upon Receptor Enzymes in chapter Biosignalling of Biochemistry

How many types of signal transducers are there?(a) 3(b) 4(c) 5(d) 6This question was addressed to me during a job interview.This interesting question is from Molecular Mechanisms of Signal Transduction in chapter Biosignalling of Biochemistry

Which of the following is not a G-protein coupled receptor?(a) Glycine receptor(b) Adrenergic receptor(c) Glutamate receptor(d) Muscarinic receptorI had been asked this question during an interview.I'd like to ask this question from G Protein topic in section Biosignalling of Biochemistry

Which out of the following is not involved in signal transduction by β-adrenergic receptor pathway?(a) GTP(b) ATP(c) cAMP(d) cGMPI have been asked this question in an interview.Asked question is from G Protein topic in portion Biosignalling of Biochemistry

SH2 domain specifically binds to _____________(a) GDP(b) Ca^+2(c) Phosphorylated tyrosine residues(d) Phosphorylated serine residuesThe question was asked in an interview.I want to ask this question from Receptor Enzymes topic in portion Biosignalling of Biochemistry

Negative regulator of ethylene response is _________(a) LPS(b) CTR1(c) BAK1(d) MAPKI have been asked this question during an interview for a job.This interesting question is from Signaling in Microorganisms and Plants in section Biosignalling of Biochemistry

Which of the following are intracellular second messengers?(a) Acetylcholine(b) Glycine(c) IP3(d) GlutamateI have been asked this question in an interview for internship.This interesting question is from Gated Ion Channels topic in portion Biosignalling of Biochemistry

In which phase of cell cycle is DNA replicated?(a) G1 phase(b) S phase(c) G2 phase(d) M phaseThis question was addressed to me in semester exam.Question is taken from Regulation of the Cell Cycle by Protein Kinases topic in portion Biosignalling of Biochemistry

Which of the following is involved in proline rich motif binding?(a) SH2(b) SH3(c) PTB(d) PHI have been asked this question in an interview for job.The above asked question is from Multivalent Scaffold Proteins and Membrane Rafts topic in section Biosignalling of Biochemistry