InterviewSolution

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51.	An E6 factor which binds to p53 and thus causes cancer is seem in case of _____________(a) Epstein Barr Virus(b) Human Papilloma Virus(c) Melanoma(d) LeukemiaThis question was posed to me in class test.The origin of the question is Apoptosis and Cancer in section Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Correct answer is (b) Human Papilloma Virus For explanation I would say: HPV or Human Papilloma cells PRODUCE the E6 FACTOR which binds p53. This in TURN prevents the activation of apoptotic PATHWAY triggered by DNA damage and leads to cell proliferation and cancer.

52.	If you inject Bcl-2 within a cell it will not undergo apoptosis.(a) True(b) FalseI had been asked this question in class test.I would like to ask this question from Apoptosis and Cancer in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Right option is (a) True The explanation is: Bcl-2 is an anti APOPTOTIC protein. The PROPER balance of the pro apoptotic and anti apoptotic PROTEINS maintains the APOPTOSIS. In this case the apoptosis will be prevented.

53.	Ataxia talengictesia is due to the defect in which of the following?(a) P53(b) Mdm2(c) Cdc25(d) Mad2The question was asked by my college professor while I was bunking the class.The doubt is from Cell Cycle Stages topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Correct answer is (B) Mdm2 Easy explanation: The defect in Mdm2 when it is unable to phosphorylate P53 in response to DNA damage causes ataxia talengictesia. It is a genetic DISORDER that often leads to CANCER.

54.	Cell size is regulated by_____________(a) Hct1(b) Cdc6(c) MDM2(d) Cln 3I have been asked this question during an internship interview.The doubt is from Cell Cycle Stages topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» The CORRECT option is (d) CLN 3 Easy EXPLANATION: The Cln 3 is responsible for regulating the CELL size. When the Cln 3 concentration in the cell is artificially increased the cell undergoes division at a smaller size.

55.	Which of the following acts as a licensing factor for replication?(a) ORC(b) Cdt(c) MCM(d) CDC42I have been asked this question by my college professor while I was bunking the class.I need to ask this question from Cell Cycle Stages topic in division Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» The correct answer is (c) MCM To elaborate: MCM ACTS as the licensing factor to set on the M PHASE of cell cycle. In its absence, the ORC although present in the nucleus can’t reinitiate REPLICATION. Cdc6 PARTICIPATES in replication and not cdc42, cdt is BOUND by geminin and is not the licensing factor.

56.	Flow cytometry uses_____________(a) Heavy isotope(b) Radioactive elements(c) Immunological techniques(d) Energy contentI got this question in quiz.My enquiry is from Flow Cytometry and Cell Sorting topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» RIGHT CHOICE is (C) Immunological techniques Explanation: The process of flow cytometry is based on immune fluorescence where a laser is used to irradiate the fluorescent PARTICLE bound to a particle that DETERMINES its fete.

57.	The target for Obimerson sodium is _________(a) P53(b) Bad(c) Bcl-2(d) IAPThis question was posed to me by my school principal while I was bunking the class.Question is taken from Apoptosis and Cancer in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» The CORRECT choice is (c) Bcl-2 To elaborate: Obimerson SODIUM when given with normal chemotherapeutic DRUGS is a Bcl-2 antisense oblimer. It prevents the expression of Bcl2 anti-apoptotic proteins in PROLIFERATIVE CELLS leading to apoptosis.

58.	Which of the following is an active cell death process?(a) Apoptosis(b) Necrosis(c) Senescence(d) LysisThe question was asked during an interview for a job.My question is based upon Apoptosis and Cancer in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» The correct answer is (a) Apoptosis For EXPLANATION: Apoptosis is an ACTIVE and REGULATED cell death process that occurs in the body. In NECROSIS the cell membrane is ruptured and so is the case in option c and d.

59.	The Spindle fibers in cell cycle are formed by ____________(a) Intermediate filaments(b) Microtubules(c) Actin(d) MyosinThe question was posed to me during an interview for a job.Question is from Cell Cycle Stages in division Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Correct option is (b) MICROTUBULES For EXPLANATION: The Microtubules are reassembled during CELL division to form the SPINDLE FIBERS. The spindle fibers bind to the chromosomes at the Kinetochores.

60.	Downregulation of caspase 9 is seen in ________________(a) Melanoma(b) Breast cancer(c) Colorectal cancer(d) Lung cancerI have been asked this question during an internship interview.I'm obligated to ask this question of Apoptosis and Cancer topic in chapter Cancer Biology & Methods in Cytogenetics of Cytogenetics
Answer» Correct answer is (c) Colorectal cancer Explanation: Reduced functioning of caspases may PREVENT APOPTOSIS THUS leading to cancer. Down regulation of CASPASE 12 is seen mostly in case of colorectal cancers.