InterviewSolution
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InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 101. |
Information flow or central dogma of modern biology isA. RNA - Proteins - DNAB. DNA -Proteins -RNAC. RNA-DNA - ProteinsD. DNA-RNA - Proteins |
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Answer» Correct Answer - D Information flow or central dogma of modern biology is DNA-RNA-Proteins. |
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| 102. |
Many non-humans model orgaisms have also been sequenced along with the human genome, these areA. Bacteria and yeastB. Plants (rice and Arabidopsis)C. Fruitfly and Coenohabditis (nematode)D. All of the above |
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Answer» Correct Answer - D Many non-human model organisms, such as bacteria, yeast, Caenorhabditis elegans (a free living non-pathogenic nematode), Drosophila (the fruit fly), Plants (rice and Arabidopsis), etc., have also been sequenced. |
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| 103. |
The application of genetic engineering is in the firld ofA. Forensic scienceB. Genetic biodiversityC. Evolutionary biologyD. All of the above |
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Answer» Correct Answer - D The application of genetic engineering is in the field of forensic science, genetic biodiversity and evolutionary biology. |
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| 104. |
Assertion. Sickle-cell haemoglobin has valine in place of glutamic acid at position 6 in the `beta` polypeptide chain. Reason. Sickle-cell anaemia is expressed only in homozygous recessive state.A. If both A and R are true and R is the correct explanation of A.B. If both A and R are true but R is not the correct explanation of A.C. If A is true but R is false.D. If both A and R are false. |
| Answer» Correct Answer - B | |
| 105. |
DNA fingerprinting in forensic science was pioneered in India byA. Lalji SinghB. H.G. KhoranaC. J.C.BoseD. M.S.Swaminathan |
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Answer» Correct Answer - A DNA finger printing in forensic science was pioneered in India by Lalji. |
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| 106. |
To initiate translation, the mRNA first binds toA. the smaller ribosomal sub-unitB. the larger ribosomal sub-unitC. the whole ribosomeD. no such specificity exists. |
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Answer» Correct Answer - a The cellular factory responsible for synthesising proteins is the ribosome.The ribosome consists of structural RNAs and about 80 different proteins, In its exists as two subunits as a large subunit and a small subunit.When the small subunit encounters an mRNA the process of translation of the mRNA to protein begins. |
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| 107. |
A sequence of 3 bases on tRNA which binds to mRNA codon isA. NODOCB. Nonsence codonC. AnticodonD. Both (A) and (C) |
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Answer» Correct Answer - c A sequence of 3bases on tRNA which binds to mRNA codon is anticodon. |
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| 108. |
To initaite translation the mRNA first binds toA. The smaller ribosomal sub-unitB. the larger ribosomal sub-unitC. the whole ribosomeD. no such specificity exists |
| Answer» Correct Answer - a | |
| 109. |
Select the correct matchA. Ribozyme - Nucleic acidB. `F_(2) xx` Recessive parent- Dihybrid CrossC. T.H. Morgan- TransductionD. G. Mendel - Tranformation |
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Answer» Correct Answer - a During electrophoresis, DNA is filtered through pores, based on size. It moves towards anode. |
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| 110. |
Select the correct matchA. Alec Jeffreys - Streptococcus penumoniaeB. Alec Hershey and Martha chase - TMVC. Mathew Meselson and F. Stahl - Pisum sativumD. Francois Jacob and Jacques Monad- Lac operon |
| Answer» Correct Answer - d | |
| 111. |
What is not relevant to DNA double helix ?A. One turn every `34 Å`B. Diameter `20 Å`C. Distance between adjacent nucleotides `3.4 Å`D. Back bone has alternate ribose sugar and phosphate |
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Answer» Correct Answer - D Back bone has alternate deocyribose sugar and phosphate. |
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| 112. |
Assertion : Recognition site should be perfectly single and reponsive to commonly used restriction enzymes. Reason: In pNR 322 Alien DNA is ligated generally in the area of Bam-HI site of tetracycline resistance gene.A. If both the assertion and the reason are true and the reason is a correct explanation of the assertion.B. If both the assertion and reason are true but the reason is not a correct explanation of the assetionC. If the assertion is true but the reason is falseD. If the both the assertion and reason are false |
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Answer» Correct Answer - b b) Recognition site or site where alien DNA can be inserted should be single because occurrence of more than one recognition site will cause DNA fragmentation and disturb gene cloning. |
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| 113. |
If a certain group of cells utilises the amino aciid glycine exclusively for synthesis, and if a growing culture of these cells is fed radioactive glycine, radioactivity will be found first in theA. rRNAB. mitochondrial RNAC. messenger RNAD. transfer RNA |
| Answer» Correct Answer - D | |
| 114. |
The diagram shows an important concept in the genetic implicatio of DNA. Fill in the blanks A to C. A. A- transcription , B - replication, C- James WastonB. A- translation , B- transcription, C- Erwin ChargaffC. A- transcription , B - translation , C - Francis CrickD. A- translation , B - extension , C - Rosalind Franlin |
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Answer» Correct Answer - C `DNAunderset(A)overset("Transcription")tomRNAunderset(B)overset("Translation")to"Protein"underset(C)overset("Francis Crick")to` |
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| 115. |
Which enzyme/s will be produced in a cell in which there is a nonsese mutation in the lac Y geneA. Lactose permeaseB. TransacetylaseC. Lactose permease and transacetylaseD. `beta`-galactosidase |
| Answer» Correct Answer - D | |
| 116. |
A segment of DNA, AGCTTCGAA, has lost first base. Assuming that translation starts from the next base the effect would beA. No change in polypeptide formB. Only first amino acid will be differentC. A complete change in type and sequence of amino acidsD. Last amino acid of polypeptide will be different |
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Answer» Correct Answer - C A segment of DNA, AGCTTCGAA, has lost first base. Assuming that translation starts from the next base the effect would be a complete change in type and sequence of amino acids as genetic code reads in a contiguous manner. |
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| 117. |
Crick one of the discoverer of DNA double helical stucture, was the man ofA. PhysicsB. ChemistryC. ZoologyD. Botany |
| Answer» Correct Answer - A | |
| 118. |
Which one of the following techniques is employed in human genetic counsellingA. Serological techniqueB. PolyploidyC. Genetic engineeringD. Amniocentesis |
| Answer» Correct Answer - e | |
| 119. |
particular strain of Neurospora crassa required citrulline in the medium while the wild type did not. How do you refer to the former ? Why is it so called ? |
| Answer» Auxotroph, because it needed increased nutrition (G. auxano = to increase), it needed citrulline as it lacked the gane for the enzyme that could catalyse the change of ornithine into citrulline. | |
| 120. |
The conversion of mutant type into wild type is calledA. backward mutationB. forward mutationC. inversionD. both (2) and (3) correct |
| Answer» Correct Answer - A | |
| 121. |
In a given RNA segment-AUG ACC UGG ACC CCA UCA if the first base gets mutated, the effect of this on coding by this RNA segment will result inA. a change of the first amino acid onlyB. a complete change in the types as well as the sequence of almost all amino acidsC. no change in sequence of any amino acidD. one amino acid will be less in the protein chain |
| Answer» Correct Answer - A | |
| 122. |
Assertion. One gene-one enzyme hypothesis of Beadle and Tatum is true in all cases. Reason. An enzyme always consists of more than one polypeptide chainA. If both A and R are true and R is the correct explanation of A.B. If both A and R are true but R is not the correct explanation of A.C. If A is true but R is false.D. If both A and R are false. |
| Answer» Correct Answer - D | |
| 123. |
Lac operon consists ofA. Four regulatory genes onlyB. Two regulatory genes and three structural genesC. Three regulatory genes and three structural genesD. One regulatory gene and three structural genes |
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Answer» Correct Answer - D Lac operon consists of one regulatory gene and three structural genes (z, y, a). |
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| 124. |
The lac operon consists ofA. Four regulatory genes onlyB. One regulatory gene and three structural genesC. Two regulatory genes and two structural genesD. Three regulatory genes and three structural genes |
| Answer» Correct Answer - B | |
| 125. |
Thymine differs fro uracil in havingA. `CH_(3)` groupB. `C=O` groupC. `CHO` groupD. COOH group |
| Answer» Correct Answer - A | |
| 126. |
Virus envelope is known asA. CoreB. CapsidC. virion stateD. Nucleoprotein |
| Answer» Correct Answer - B | |
| 127. |
In purines, N is at position _____in its two rinigs.A. 1,3,7,9B. 1,5C. 7,9D. 1 & 9 |
| Answer» Correct Answer - A | |
| 128. |
The one aspect which is not a salient feature of genetic code, is its beingA. SpecificB. DegenerateC. AmbigousD. Universal |
| Answer» Correct Answer - C | |
| 129. |
Satellite DNA is useful tool inA. Genetic engineeringB. Organ transplantationC. Sex determinationD. Forensic science |
| Answer» Correct Answer - D | |
| 130. |
A nucleoside differs from a nucleotide. It lacks theA. BaseB. SugarC. Phosphate groupD. Hydroxyl group |
| Answer» Correct Answer - c | |
| 131. |
A nucleoside is formed through a N-glycosidic linkage by joiningA. Phosphate group with nitrogen baseB. Nitrogen base with nitrogen baseC. Nitrogen base with pentose sugarD. Pentose sugar with phosphate group |
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Answer» Correct Answer - C A nucleoside is formed through a N-glycosidic linkage by joining nitrogen base with pentose sugar. |
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| 132. |
A unit composed of a sugar and base linked by `beta` glycosidic bond is known as aA. NucleotideB. NucleosideC. GlycosideD. Purine |
| Answer» Correct Answer - b | |
| 133. |
The frequency of an allele in an isolated population may change due toA. Gene flowB. MutationC. Genetic driftD. Natural selection |
| Answer» Correct Answer - c | |
| 134. |
Following the collision of two trains a large number of passengers are killed. A majority of them are beyond recongnition. Authorites want to hand over the dead to their relatives. Name a modern scientific method and write the procedure that would help in the identification of kinship. |
| Answer» DNA fingerprinting. | |
| 135. |
During the replication of DNA, the synthesis of DNA as lagging strand takes place in segments, these segments are calledA. Double helix segmentsB. Satellite segmentsC. Kornberg segmentsD. Okazaki segments |
| Answer» Correct Answer - D | |
| 136. |
A DNA sequence undergoes three subsequent point mutations which result in subsequent changes in transcription of mRNA as shown below: select the correct sequence of point mutations that occurred in the DNA.A. Missense mutation `to` Frame shift mutation `to` Nonsense mutationB. Silent mutation `to` Nonsense mutation `to` Frameshift mutationC. Silent mutations `to` Frame shift mutation `to` Nonsense mutationD. Missense mutation `to` Frameshift mutation `to` Silent mutation |
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Answer» Correct Answer - c |
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| 137. |
Name one amino acid, which is coded by only one codon. |
| Answer» Correct Answer - Methionine. | |
| 138. |
If an inheritable mutation is observed in a population at high frequency, it is referred asA. DNA polymorphismB. Expressed sequence tagC. Sequence annotationD. Linkage |
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Answer» Correct Answer - A `**" "`Allelic sequence variation has traditionally been described as a DNA polymorphism if more than one variant (allele) at a locus occurs in human population with a frequency greater than 0.01. `**" "`If an inheritable mutation is observed in a population at high frequency, it is referred as DNA polymorphism. |
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| 139. |
Which one is not a termination codon ?A. UAAB. UAGC. AUGD. UGA |
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Answer» Correct Answer - C AUG is not a termination codon, it is initiator codon. |
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| 140. |
What is correctA. Introns are present in mRNA and exons in tRNAB. Codons are present in mRNA and anticodons in tRNAC. Every intron is a set of three terminator codonsD. Exons are present in eukaryotes and introns in prokaryotes |
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Answer» Correct Answer - B Codons are present in mRNA and anticodons in tRNA. |
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| 141. |
Select the incorrect statement (a) Six codons do not code for any amino acid (b) Codon reading of mRNA is contiguous (c) Three codons function as stop codons (d) Initiator codon AUG codes for methionineA. a alone is incorrectB. a,b and d are incorrectC. a, b and c are incorrectD. b, c and d are incorrect |
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Answer» Correct Answer - A Three codons (UAA, UAG and UGA) do not code for any amino acid. |
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| 142. |
Which one of the following pairs is correctly matched with regard to the codon and the amino acid coded by it `?`A. UUA-valineB. AAA-lysineC. AUG-cysteineD. CCC-alanine |
| Answer» Correct Answer - B | |
| 143. |
Which one of the following pairs is correctiy matched with regard to the codon and the amino acid coded by itA. UUA- ValineB. AAA-LysineC. AUG - CysteineD. CCC -Alanine |
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Answer» Correct Answer - b b) Codon AAA and AaG code for lysine amino acid. |
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| 144. |
The genetic code is nonoverlapping and degenerate. Is it so? |
| Answer» Correct Answer - Yes | |
| 145. |
Assertion. The genetic code is degenerate. Reason. Most amino acids are coded by more than one codon.A. If both A and R are true and R is the correct explanation of A.B. If both A and R are true but R is not the correct explanation of A.C. If A is true but R is false.D. If both A and R are false. |
| Answer» Correct Answer - A | |
| 146. |
a) Write the specific features of the genetic code AUG. b) Genetic codes can be universal and degenerate. Write about them, giving one example of each. c) Explain aminoacylation of the tRNA. |
| Answer» (a) AUG has dual function. (i) It codes for Methionine (met.) (ii) It also acts as initiator codon. | |
| 147. |
Because most of the amino acids are represented by more than one codons, the genetic code is said to beA. universalB. degeneratieC. overlappingD. commaless |
| Answer» Correct Answer - B | |
| 148. |
The genetic code is said to be degenerate and is universal which means that `:` (i) codons are common for higher and lower organisms (ii) amino acids may have more than one codon (iii) all amino acids have more than one codon Out of the above statements, correct statement is `:`A. 1,2,3 correctB. 1,2 correctC. 2,4 correctD. 1,3 correct |
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Answer» Correct Answer - D `**" "`All amino acids not have more than one codon. (e.g., tryptophan and methionine have only one codon). `**" "`Codons are found in bacteria. |
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| 149. |
In the genetic code dictionary, how many codons are used to code for all the 20 essential amino acids ?A. 61B. 60C. 20D. 64 |
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Answer» Correct Answer - A Out of 64 codons three (UAA, UAG , UGA) are chain terminating codons the translating mechanism is not able to read these codons and 61 codons are used to code all the 20 essential amino acids. |
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| 150. |
(a) What did Meselson and Stahl observe when : (i) They cultured E. coli in a medium containing `""^(15)NH_(4)Cl` for a few generations and centrifuged the content (ii) They transferred one such bacterium to the normal medium of `NH_(4)CI` and cultured for 2 generations (iii) What did Meselson and Stahl conclude from this experiment ? Explain with the help of diagram. (iv) Which is the first genetic material ? Give reasons in support of your answer. |
| Answer» Correct Answer - (i), (ii) and (iii) | |