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At what maternal age the probability of having a child with Down’s syndrome is increased drastically?(a) 25(b) 30(c) 35(d) 45This question was addressed to me in unit test.I want to ask this question from Chromosomal Abnormalities : Aneuploidy topic in portion Chromosomal Basis of Inheritance of Cytogenetics

Answer»

The correct OPTION is (c) 35

Explanation: After the age of 35 the PROBABILITY of non-disjunction in GAMETE leading to Down’s syndrome INCREASES to 1/290. With increasing age it increases still further.



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