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Right OPTION is (b) The enzymes they produce are always very unstable

The best I can explain: The enzymes produced are stable and functional at a PARTICULAR temperature but non- functional and unstable BEYOND the RANGE of another temperature.

The correct choice is (d) 700 repeats of CGG

To explain: The NORMAL number of CGG repeats in an individual is about 6-50. If a daughter has 50-200 repeats then the NEXT GENERATION is likely to have 200-1300 repeats leading to the DISEASE. However, the daughter doesn’t show the defect.

The correct option is (b) False

To explain: LMB or leptomycin B treatment prevents the EXPORT by CRM1 as it BINDS to the NES binding site. However, it doesn’t affect export of mRNA which SHOWS that is VIA some other MECHANISM.

Right answer is (b) NLS

To explain I would say: The importins are mainly needed for proteins that are greater than 45KDa so that they can’t DIFFUSE randomly. They must have a nuclear localization SIGNAL which is a REPEAT of lysine rich SEQUENCES.

The correct choice is (a) True

The explanation: There are some nucleoporins lining the NUCLEAR PORE which have long hydrophobic regains separated by FG domains. They are the FG RICH proteins. They are not only PRESENT in the central PLUG but also attached to nuclear basket.

Correct choice is (c) CAG

To explain: CAG repeat numbers determine HUNTINGTON’s DISEASE in an INDIVIDUAL. CGG repeats are determinant for the fragile X chromosome.

The correct answer is (C) RAN.GDP-importin

Easiest explanation: The HYDROLYSIS of the GTP REDUCES the interaction of Ran with the importin bound to cargo. This results in the release of the cargo into the cytosol.

Correct answer is (C) siRNA against TAP will result in cytosolic ACCUMULATION of proteins with NLS

For explanation: TAP is the exportin that EXPORTS the MRNA out of the nucleus. It can bind to the poly A+ region of the mRNA and with help of Aly/REF protein it helps in EXPORT.

The CORRECT ANSWER is (d) NTF2

Explanation: NTF2 helps RAN to return to the nuclear side of the membrane, and then it DIFFUSES BACK to the cytosol. All other OPTIONS here have a greater concentration in the nuclear half.

The correct answer is (d) 300%

Best explanation: PKU is a disease where the individual can have a normal life if they are on a special diet. Then the PERSONS are able to live and reproduce and pass on the disease, who would otherwise have died. This COULD result in 300 % increase in the PKU in the next 30 years.

Right ANSWER is (a) The father having 50 nt repeats or above leads to DISEASE in DAUGHTER

For explanation: The father having a repeat beyond a PARTICULAR threshold say 50 will pass the gene to daughter. In the daughter due to anticipation the gene COULD be 50-200 times repeated. Only in the next generation number of repeat will be 200-1300 and they will show the phenotype.

The correct answer is (a) True

Explanation: If the DIET of the PERSON is properly controlled such that only SPECIFIC amino acids are taken, then the individual can BEHAVE as normal.

Correct option is (b) False

The explanation: The NTM or non-transmitted males will pass the disease to the DAUGHTER who can pass it to both her sons and daughters. It is not like the X LINKED GENE inheritance.

Correct answer is (d) Non-hereditary

The best I can EXPLAIN: PHECOMELIA is a PHENOCOPY produced when the mother takes SEDATIVE like thalidomide during child birth. It is non-hereditary.

Correct option is (b) False

The explanation: Deafness can be caused by the presence of DUEL copy of homozygous recessive allele. Or it can be caused if the expectant MOTHER is affected by RUBELLA virus in the 1st 12 weeks of PREGNANCY.

Right answer is (b) Leucine

Explanation: The NES or Nuclear Export SEQUENCE that is RECOGNIZED in the CARGO to be exported is leucine rich. This MARKS it for export.

The CORRECT choice is (d) Phenocopy

Explanation: In phenocopy a DRUG or a CONDITION MIMICS the EFFECT of some disease. It is an environmental effect and non-heritable condition.

Right choice is (B) The NUMBER of repeats

Easy EXPLANATION: Dynamic mutation is the function of the number of copies of a PARTICULAR gene present in an individual. The replication PRODUCT of a dynamic mutation will usually have a different likelihood of mutation than its predecessor.

The correct CHOICE is (d) The coat colour of that area will be darker

The explanation is: In Himalayan rabbits, like Seamese CATS the body TEMPERATURE affects the coat colour. Parts that are cooler have a darker colour than the warmer parts. Here the cooler part will gradually accumulate the dark colour ENZYME which OTHERWISE is unstable at the main body parts and give the pattern.

Correct option is (d) Genotype

To EXPLAIN: Genotype is not DIRECTLY an environmental factor but it is rather influenced by the different environmental factors. The other OPTIONS given are determined by environment.

Correct option is (C) 36

The EXPLANATION: If the number of CAG REPEATS in an individual is below 36 then the person will show normal phenotype. If larger than that then Huntington’s disease will result.

Right answer is (B) DECREASES

Explanation: In the nuclear side of the cytoplasm the interaction of the IMPORTING with the Ran.GTP complex decreases its affinity for NLS which releases the CARGO.

Right ANSWER is (c) During SPLICING

To explain: The study of improperly spliced mRNA shows that Aly/REF is ADDED to PROTEINS during splicing by the SR proteins that MARK the exon / intron junction.

Right ANSWER is (b) 8, nuclear

For EXPLANATION: 8 filaments about 100nm in length come out from the nuclear side of the NPC and they are JOINED to the ring at the end FORMING a nuclear basket.

Right option is (a) True

Easiest explanation: Huntigton’s is an X linked dominant disease that is expressed in an individual beyond 30 years of AGE if they have more than 36 CAG repeats. If the number of repeats of CAG is MUCH more the gene can FIND its expression at 20 years of age as well.

The CORRECT answer is (a) HERITABLE

Best explanation: DYNAMIC mutation is an unstable genetic phenomenon which can be passed to the next generation, so it is heritable.

Right answer is (b) Against Darwin’s theory

Best explanation: Modern medicine is dysgenic as it COUNTERS the effect of natural selection by Darwin. As a result, children who would ordinarily have DIED young now survive to have children of their own, which inevitably LEADS to GENETIC degradation of the entire society.

Right choice is (c) The number of repeat BEYOND a particular threshold leads to improper replication

To EXPLAIN I would say: In case of anticipation there is a normal range of a number of REPEATS which can be faithfully replicated. If the number of repeats is beyond a threshold then the faithful replication is LOST and massive increase in number is seen in the next generation and YET more in the next.

Right option is (C) 2-5 years life expectancy

Best explanation: In case of Duchenne muscular DYSTROPHY the age of ONSET of the disease is about 2-5 years of age. This is a LETHAL gene which is X linked recessive.

Right answer is (c) Ran. GTP

Best explanation: Only Ran. GTP of the Four can be seen in the nuclear side of the membrane while the REST can be seen in the CYTOSOLIC END of the NPC.