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Foe fragile X chromosome which of the following is wrong?(a) The father having 50 nt repeats or above leads to disease in daughter(b) Daughter has 50-200 repeats(c) The grandson has 200-1300 repeats(d) The grandson shows the disease phenotypeThis question was posed to me in an online quiz.This key question is from Dynamic Mutation and Anticipation in portion Nuclear Export & Post Mendelian Genetics of Cytogenetics

Answer»

Right ANSWER is (a) The father having 50 nt repeats or above leads to DISEASE in DAUGHTER

For explanation: The father having a repeat beyond a PARTICULAR threshold say 50 will pass the gene to daughter. In the daughter due to anticipation the gene COULD be 50-200 times repeated. Only in the next generation number of repeat will be 200-1300 and they will show the phenotype.



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