

InterviewSolution
This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
1. |
________________ aneuploidy is better tolerated.(a) Nullisomic(b) Autosomal(c) Sex chromosomal(d) Chromosome 13I had been asked this question in unit test.Query is from Chromosomal Abnormalities : Aneuploidy in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (c) Sex chromosomal |
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2. |
In an experiment, you culture the anthers and leaves of a flower. You see the plants so generated are_____________(a) Triploid(b) Monoploid and diploid(c) Diploid and triploid(d) DiploidThis question was posed to me in unit test.Question is from Chromosomal Abnormalities : Euploidy in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (b) MONOPLOID and DIPLOID |
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3. |
Deletion in sex chromosome is better tolerated than that in autosome.(a) True(b) FalseI had been asked this question in homework.This interesting question is from Chromosomal Abnormalities : Deletion in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct choice is (a) True |
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4. |
The Streisinger’s model explains__________(a) Frame shifts(b) Transposition(c) Inversion(d) TransitionThe question was asked during an interview.My question is from Chromosomal Abnormalities : Duplication in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct answer is (a) Frame shifts |
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5. |
In an experiment you develop immune response in mice against salmonella flagellar antigen. However, you observe the infection still persisted. Which if a likely possibility if immune system is functioning properly?(a) Salmonella shed its flagella(b) The antigen lost its specificity gradually(c) The flagella antigen changed(d) Infection was not due to salmonellaI got this question by my school teacher while I was bunking the class.Question is from Chromosomal Abnormalities : Translocation topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct answer is (c) The flagella antigen changed |
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6. |
What percentage of the human genome is transposition related?(a) 2%(b) 10%(c) 50%(d) 80%The question was posed to me during an online interview.This interesting question is from Chromosomal Abnormalities : Translocation in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» RIGHT choice is (c) 50% The explanation is: 50% of the human and maize genetic elements in involved in transposition. This is a HUGE amount and shows the evolutionary IMPORTANCE of transposition. |
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7. |
Choose the wrong option.(a) Paracentric inversion cross over products is non-viable(b) Pacentric non-cross over gametes segregates normally(c) Double cross over in paracentric inversion is lethal(d) There is genetic imbalance in gametes produced by paracentric inversion cross overI got this question in an online interview.Question is from Chromosomal Abnormality : Inversion in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right OPTION is (C) DOUBLE cross over in paracentric inversion is lethal |
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8. |
Choose the wrong option.(a) Transposons have trasposase along with other genes(b) Transposons lack inverted terminal repeats(c) Transposons have insertion sequences within it(d) Class III transposons are called MITESI had been asked this question in a national level competition.My doubt is from Chromosomal Abnormalities : Translocation topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» RIGHT ANSWER is (b) Transposons lack inverted terminal repeats Explanation: Transposons have Inverted Terminal Repeats, further they may have two INSERTION sequences at two ends. They have many GENES which often include antibiotic resistance gene. |
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9. |
If there are two sequences CGCGCGCG and ATATATAT, which will have a higher probability of being duplicated?(a) ATATATATAT(b) CGCGCGCGCG(c) Both will have equal probability(d) Both are unlikely to be duplicatedI got this question in quiz.I would like to ask this question from Chromosomal Abnormalities : Duplication topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct choice is (c) Both will have equal probability |
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10. |
Which of the following transpose using RNA intermediate?(a) Class I transposon(b) Class II transposon(c) Class III transposon(d) Class IV transposonI have been asked this question at a job interview.This is a very interesting question from Chromosomal Abnormalities : Translocation in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct answer is (a) Class I TRANSPOSON |
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11. |
The chromosomal theory of inheritance violates which of the following laws?(a) Law of dominance(b) Law of segregation(c) Law of independent assortment(d) NoneI got this question during a job interview.I want to ask this question from Chromosomal Theory of Inheritance topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right option is (d) None |
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12. |
Extreme klinefelter is an example of _____________________(a) Monosomy(b) Trisomy(c) Disomy(d) TetrasomyThis question was posed to me in a job interview.The query is from Chromosomal Abnormalities : Aneuploidy in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right choice is (d) Tetrasomy |
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13. |
Sexual mosaics lead to formation of _______________(a) Female from male egg(b) Gynandromorph(c) Klinefelter(d) TrisomyI have been asked this question in a national level competition.My doubt stems from Chromosomal Abnormalities : Aneuploidy topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right answer is (B) Gynandromorph |
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14. |
Chromosome ____________ trisomy leads to Edward’s syndrome.(a) 12(b) 13(c) 18(d) 21This question was addressed to me during an interview.Origin of the question is Chromosomal Abnormalities : Aneuploidy topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right answer is (C) 18 |
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15. |
Turner’s syndrome is a result of _________________(a) Nullisomy(b) Monosomy(c) Trisomy(d) PolysomyThis question was addressed to me in an interview for internship.I need to ask this question from Chromosomal Abnormalities : Aneuploidy in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct OPTION is (b) Monosomy |
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16. |
In aneuploidy the entire set of chromosome is not involved in duplication of deletion.(a) True(b) FalseThis question was addressed to me during an online exam.This interesting question is from Chromosomal Abnormalities : Aneuploidy in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct choice is (a) True |
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17. |
Farmers often practice polyploidy as ____________________(a) It makes the plants more durable(b) They take longer time to undergo meiosis(c) It increases complexity and there is a hope of new species(d) It produces larger plant parts and productsThis question was addressed to me by my school teacher while I was bunking the class.My question comes from Chromosomal Abnormalities : Euploidy topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right answer is (d) It PRODUCES larger plant PARTS and products |
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18. |
Which of the following is not a possible cause of lethality of individuals carrying a deletion mutation?(a) Genes that are not haplo sufficient doesn’t produce adequate gene product(b) Genomic imbalance(c) Unmasking of lethal recessive alleles(d) Lack of diversityI had been asked this question by my school teacher while I was bunking the class.My question comes from Chromosomal Abnormalities : Deletion in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (d) Lack of DIVERSITY |
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19. |
Tandem duplication creates ____________and reverse tandem creates_____________(a) Buckling, looping(b) Hairpin, buckling(c) Buckling, Hairpin(d) Loop with turn, hairpinI had been asked this question in my homework.Asked question is from Chromosomal Abnormalities : Duplication in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» RIGHT choice is (c) Buckling, HAIRPIN Explanation: In case of tandem REPEAT the same sequence in same order is repeated. As parent chromosome has only ONE copy of that sequence the daughter bulges out. This, causes buckling. In reverse tandem the duplication is INVERTED in sequence which leads to formation of hairpin. |
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20. |
There are two chromosomes 1- A—B—C—D—E and 2- F—G—H— I, if A—B—C and F—G undergo reciprocal translocation what will not be true?(a) New sequence at 1 will be C—D—E—F—G(b) The 1 will then pair with both 1’ and 2’(c) Pairing will be between same gene loci only(d) 2nd chromosome will become longerThis question was addressed to me during a job interview.I need to ask this question from Chromosomal Abnormalities : Translocation topic in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The CORRECT OPTION is (a) New sequence at 1 will be C—D—E—F—G |
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21. |
Which of the following is not true about inversion?(a) Inverted chromosomes are generally viable(b) Inversion can cause chromosome breakage(c) Two DNA strands with an inverted segment will not pair(d) Inversion including centromere is known as paracenricThis question was addressed to me during an internship interview.This key question is from Chromosomal Abnormality : Inversion topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct option is (C) Two DNA strands with an inverted segment will not pair |
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22. |
Consider this sequence A—O—B —C—D—E—F, be a DNA sequence where O is the centromere. Which of the following will be a pericentric inversion?(a) A—O—B—D—E—F(b) B—O—A—D—E—F(c) D—B—O—A—E—F(d) A—O—E—D—B—FI have been asked this question in my homework.This intriguing question comes from Chromosomal Abnormality : Inversion topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right choice is (d) A—O—E—D—B—F |
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23. |
____________ is mandatory for autonomous transposition.(a) Internal gene(b) Transposase(c) 3’ concensus of region upstream to transposition(d) Branch point AThis question was posed to me in an interview for job.This question is from Chromosomal Abnormalities : Translocation topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct choice is (b) Transposase |
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24. |
Choose the odd one out?(a) Leaf(b) Endosperm(c) Fertilized egg(d) PetalsThis question was addressed to me during an internship interview.The query is from Chromosomal Abnormalities : Euploidy in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct choice is (B) Endosperm |
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25. |
In drosophila male there is no cross over suppression due to pericentric inversion as___________(a) They have only one set of chromosome(b) They always have double cross over(c) They never recombine(d) They don’t undergo meiosisThis question was posed to me by my college director while I was bunking the class.Question is taken from Chromosomal Abnormality : Inversion topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» CORRECT option is (c) They never recombine To explain: Drosophila males don’t recombine due to the ABSENCE of synaptonemal COMPLEX formation. THUS there is no question of recombination for it to be suppressed. |
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26. |
Which of the following is not true about the Notch gene in Drosophila?(a) It causes a special indentation of the wing margin(b) It is expressed in heterozygous form(c) Notch is lethal in homozygous form(d) Notch is recessive to FacetThis question was addressed to me during an online interview.My question is taken from Chromosomal Abnormalities : Deletion topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct OPTION is (d) Notch is recessive to FACET |
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27. |
What are the results of pericentric inversion with single crossing over?(a) Two normal, one dicentric and one acentric chromosome(b) 2 dicentric and 2 acentric chromosomes(c) Four normal chromosomes with centriomere in different positions(d) 3 normal chromosome, one abnormal acentric chromosomeI had been asked this question in an internship interview.My question is from Chromosomal Abnormality : Inversion topic in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct option is (a) Two normal, one dicentric and one acentric CHROMOSOME |
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28. |
If a part of the chromosome was transferred to a non-homologous chromosome say 1 to 1’. Then which of the following is not true?(a) The pairing in meiosis will be affected(b) The chromosome will be torn apart while segregation(c) In most of the cases, the resultant gamete will be non-viable(d) The pairing will be between 4 homologous chromosomesThis question was addressed to me in my homework.The question is from Chromosomal Abnormalities : Translocation topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (b) The chromosome will be torn apart while segregation |
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29. |
In animals polypoidy is rarely practiced as _______________(a) Giants are harder to train and take care of(b) Increase in size is not appreciable(c) It is often sterile(d) Animal cells are resistant to colchicineThis question was addressed to me in quiz.Query is from Chromosomal Abnormalities : Euploidy in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct choice is (b) INCREASE in size is not appreciable |
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30. |
You generate a fluorescent probe against a gene that has been deleted. You expose the DNA to the probe and observe it under fluorescent microscope. What will you see?(a) Fluorescence will correspond to the gene of interest(b) There will be a number of regions that emit fluorescence(c) Most parts of the chromosome emits fluorescence(d) Nothing is seen under fluorescence microscopeI had been asked this question in semester exam.This is a very interesting question from Chromosomal Abnormalities : Deletion topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» RIGHT answer is (d) Nothing is seen under fluorescence microscope Easiest explanation: The gene CORRESPONDING to the probe labeled with fluorescence is deleted. Thus, probe can’t BIND the DNA. In this CASE no fluorescence should be seen on the chromosome. |
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31. |
If a gene undergoes duplication and one of the duplicated copy is mutated to render unexpressed protein. What will be the effect on phenotype?(a) Mutant phenotype(b) Normal phenotype(c) Expression of the mutant gene is less than that would occur if both copy active(d) The gene not expressed at allThe question was asked in an international level competition.The query is from Chromosomal Abnormalities : Duplication in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct ANSWER is (b) Normal phenotype |
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32. |
Which of the following could be due to duplication?(a) Co-dominance(b) Dominance(c) Incomplete dominance(d) PleiotropyThis question was addressed to me by my school teacher while I was bunking the class.This intriguing question originated from Chromosomal Abnormalities : Duplication topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct option is (d) Pleiotropy |
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33. |
In pericentric inversion, the inversion loop involves __________ strands.(a) 1(b) 2(c) 3(d) 4The question was asked at a job interview.My doubt stems from Chromosomal Abnormality : Inversion in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right option is (d) 4 |
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34. |
You observe a genetic trait which is a common occurrence in the male of a particular pedigree, this is possibly a ______________(a) X linked(b) Y linked(c) X linked recessive(d) Y linked dominantI got this question by my school teacher while I was bunking the class.I want to ask this question from Chromosomal Theory of Inheritance topic in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right answer is (b) Y linked |
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35. |
Which human chromosomes are involved in Down’s syndrome?(a) 6(b) 14 and 21(c) 8 and 12(d) X and YI had been asked this question in class test.Question is taken from Chromosomal Abnormalities : Duplication topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The CORRECT answer is (b) 14 and 21 |
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36. |
The probability of aneuploidy in offspring increases with age as _________________(a) Chromosomes tend to lose information with age(b) Pairings at dichtyotene stages are gradually lost(c) Ability of fertilization with age is gradually lost(d) Chromosomal aberration with ageI had been asked this question in class test.My question comes from Chromosomal Abnormalities : Aneuploidy topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct choice is (b) PAIRINGS at dichtyotene stages are gradually lost |
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37. |
If the XIC passes to chromosome 3 in a human what will be the result?(a) Chromosome 3 will have one more protein to express(b) Human race will divide into two species(c) Chromosome 3 will be inactivated(d) There will be sticking of chromosome 3 with other chromosomesI had been asked this question in semester exam.Question is taken from Chromosomal Abnormalities : Translocation in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (c) Chromosome 3 will be inactivated |
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38. |
Which of the following is not a type of translocation?(a) Simple(b) Reciprocal(c) Tandem(d) IntercalaryThis question was addressed to me by my school teacher while I was bunking the class.This intriguing question comes from Chromosomal Abnormalities : Translocation topic in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right option is (c) TANDEM |
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39. |
A male bee can’t have a________________(a) Mother(b) Faher(c) Grand father(d) Grand motherI had been asked this question in an internship interview.This interesting question is from Chromosomal Abnormalities : Euploidy in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The CORRECT OPTION is (c) Grand father |
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40. |
In translocating gene fragment which part is responsible for translocation?(a) The LTR(b) The transcribed gene(c) The non-coding part of gene(d) The surrounding sequencesI got this question in an online interview.I want to ask this question from Chromosomal Abnormalities : Translocation in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct ANSWER is (a) The LTR |
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41. |
If you cross a red eyed pure breeding female Drosophila with a white eyed male, then the F1 males so produces were crossed with white eyed male, what will be the eye colour of their daughters and sons in F2?(a) Both daughters and sons red eyed(b) Daughters with both eye colour while sons with white eye(c) Both daughters and sons with both eye colours(d) Daughters with red eye and sons with white eyesI have been asked this question in an interview.Enquiry is from Chromosomal Theory of Inheritance in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct choice is (d) Daughters with red eye and sons with white eyes |
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42. |
Which of the following is an example of trisomy ________________(a) Endosperm(b) Klinefelter(c) Turner(d) XerodermaThis question was addressed to me in an online interview.This intriguing question comes from Chromosomal Abnormalities : Aneuploidy topic in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Right answer is (b) Klinefelter |
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43. |
Euploidy is a form of allopoliplody.(a) True(b) FalseThis question was posed to me in an interview.This interesting question is from Chromosomal Abnormalities : Euploidy topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct ANSWER is (b) False |
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44. |
The appearance of a recessive phenotype due to deletion of dominant gene is called_______________(a) Hemi-dominance(b) Pseudo dominance(c) Imperfect dominance(d) Co-dominanceI have been asked this question during an online interview.This interesting question is from Chromosomal Abnormalities : Deletion in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct CHOICE is (b) Pseudo DOMINANCE |
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45. |
Which of the following is not seen in cut-paste transposition, but seen in copy-paste method?(a) Synaptic complex(b) Strand transfer(c) Transposase(d) ResolvaseThe question was posed to me in an internship interview.The above asked question is from Chromosomal Abnormalities : Translocation topic in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» CORRECT answer is (d) Resolvase For EXPLANATION I would say: In addition to what is required in cut-paste mechanism, replicative transposition also REQUIRES enzyme resolvase to RESOLVE the structure FORMED after strand transfer reaction. |
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46. |
If a gamete has 16 chromosomes, what will be the number of chromatids before anaphase 1?(a) 8(b) 16(c) 32(d) 64I got this question during an interview for a job.This interesting question is from Chromosomal Theory of Inheritance topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (d) 64 |
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47. |
Which of the following pairing will not occur during meiosis of tetraploid?(a) Two bivalent(b) One bivalent and two univalent(c) Trivalent and univalent(d) QuadrivalentThe question was asked in a national level competition.The question is from Chromosomal Abnormalities : Euploidy in division Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct option is (b) One bivalent and two UNIVALENT |
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48. |
Yellow colour of mouse is generated by _________ mutation.(a) Duplication(b) Deletion(c) Inversion(d) TranslocationThis question was posed to me at a job interview.I want to ask this question from Chromosomal Abnormalities : Deletion in portion Chromosomal Basis of Inheritance of Cytogenetics |
Answer» Correct choice is (B) Deletion |
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49. |
Deletion of a region led to over expression of a gene X. What do you conclude from this observation?(a) Part of gene X is mutated(b) Promoter of gene X is deleted(c) Regulator of gene X is deleted(d) No effect on gene X or its regulatorsI have been asked this question in an international level competition.Question is from Chromosomal Abnormalities : Deletion topic in chapter Chromosomal Basis of Inheritance of Cytogenetics |
Answer» The correct choice is (c) Regulator of gene X is deleted |
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50. |
What will be the effect of the deletion mutation of a gene at the telomere?(a) Organism will dye(b) Organism will develop serious hazards due to absence of the gene and its product(c) Mild effect on the phenotype(d) No effectI had been asked this question during an internship interview.This intriguing question originated from Chromosomal Abnormalities : Deletion topic in section Chromosomal Basis of Inheritance of Cytogenetics |
Answer» RIGHT choice is (d) No effect Easy explanation: The GENES at the TELOMERE are silenced, and never expressed. It is in form of heterochromatin inaccessible to the transcription machinery. Thus, deletion of a gene that wasn’t expressed to start with doesn’t make MUCH difference. |
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