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Which of the following individuals will have fragile X chromosome?(a) 6 repeats of CGG(b) 50 repeats of CGG(c) 150 repeats of CGG(d) 700 repeats of CGGI have been asked this question at a job interview.Enquiry is from Dynamic Mutation and Anticipation topic in section Nuclear Export & Post Mendelian Genetics of Cytogenetics

Answer»

The correct choice is (d) 700 repeats of CGG

To explain: The NORMAL number of CGG repeats in an individual is about 6-50. If a daughter has 50-200 repeats then the NEXT GENERATION is likely to have 200-1300 repeats leading to the DISEASE. However, the daughter doesn’t show the defect.



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