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Colchicine is used to cause______________(a) Mitotic non-disjunction(b) Meiotic non-disjunction(c) Mitotic disjunction(d) Meiotic disjunctionI had been asked this question in an internship interview.The above asked question is from Chromosomal Abnormalities : Euploidy in section Chromosomal Basis of Inheritance of Cytogenetics

Answer»

The correct CHOICE is (a) Mitotic non-disjunction

Easiest explanation: Colchinine causes an arrest in anaphase which leads to mitotic non-disjunction HALTING the mitosis. This leads to DOUBLING of chromosome as the DUPLICATED chromatins fail to separate.



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