Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.(a) True(b) FalseI have been asked this question in class test.The query is from Genome Sequencing topic in portion Genome Mapping, Assembly and Comparison of Bioinformatics

Despite the multiple coverage, sometimes certain genomic regions remai

1.	Despite the multiple coverage, sometimes certain genomic regions remain unsequenced, mainly owing to cloning difficulties.(a) True(b) FalseI have been asked this question in class test.The query is from Genome Sequencing topic in portion Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Right option is (a) True Easy explanation: In such MENTIONED cases, the REMAINDER gap sequences can be obtained through EXTENDING sequences from regions of known genomic sequences using a more traditional PCR technique. That which REQUIRES the use of custom primers and performs genome walking in a stepwise fashion. This STEP of genome sequencing is also known as finishing, which is followed by computational assembly of all the sequence data into a final complete genome.

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