If the centroid structure is different from the minimum free-energy structure, the centroid structure is often closer to the phylogenetic prediction and contains fewer base pairs, or fewer false-positive base pair predictions, than the minimum free-energy prediction.(a) True(b) FalseThis question was posed to me in an interview for job.I'm obligated to ask this question of Searching Genomes for RNA & RNA Structure Modeling Applications in division RNA Structure Prediction of Bioinformatics

If the centroid structure is different from the minimum free-energy st

1.	If the centroid structure is different from the minimum free-energy structure, the centroid structure is often closer to the phylogenetic prediction and contains fewer base pairs, or fewer false-positive base pair predictions, than the minimum free-energy prediction.(a) True(b) FalseThis question was posed to me in an interview for job.I'm obligated to ask this question of Searching Genomes for RNA & RNA Structure Modeling Applications in division RNA Structure Prediction of Bioinformatics
Answer» The correct choice is (a) True Explanation: The point is to show a structure that REPRESENTS a GROUP of structures rather than a single predicted structure. Many long RNA sequences, such as viral genomes or MRNA, may not have a single structure but instead have a dynamic structure that has some conserved features but also varies and CHANGES, and these many conformations may all EXIST simultaneously in the cell.

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