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In CATH, Structural domain separation is carried by ___________(a) manual comparison only(b) computer programs only(c) human expertise only(d) a combined effort of a human expert and computer programsI got this question in a national level competition.Question is from Protein Structure Classification topic in portion Structural Bioinformatics of Bioinformatics

Answer»

Correct choice is (d) a combined effort of a human expert and computer programs

Explanation: CATH classifies proteins based on the automatic structural alignment program SSAP as well as MANUAL comparison. Structural domain separation is carried out also as a combined effort of a human expert and computer programs. Individual domain structures are classified at FIVE major levels: CLASS, ARCHITECTURE, fold/topology, homologous superfamily, and homologous family.



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