Leucine zipper domains are a special type of coiled coils found in transcription regulatory proteins which contain two anti parallel α-helices held together by hydrophobic interactions of leucine residues.(a) True(b) FalseI got this question in homework.My doubt is from Coiled Coil Prediction in division Secondary Structure Prediction of Bioinformatics

Leucine zipper domains are a special type of coiled coils found in tra

1.	Leucine zipper domains are a special type of coiled coils found in transcription regulatory proteins which contain two anti parallel α-helices held together by hydrophobic interactions of leucine residues.(a) True(b) FalseI got this question in homework.My doubt is from Coiled Coil Prediction in division Secondary Structure Prediction of Bioinformatics
Answer» RIGHT option is (a) True To explain: The heptad repeat pattern is L-X(6)-L-X(6)-L–X(6)-L. This repeat pattern alone can sometimes allow the domain detection, albeit with high rates of false positives. The REASON for the high false-positive rates is that the CONDITION of the sequence region being a coiled coil CONFORMATION is not satisfied. To address this problem, algorithms have been developed that take into account both leucine repeats and coiled coil conformation to give accurate prediction.

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