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Microsome are selective to ____________(a) Water-soluble drugs(b) Lipid soluble drugs(c) Acidic drugs(d) Basic drugsThis question was posed to me in a national level competition.My question is taken from Drugs Biotransformation topic in chapter Biotransformation of Drugs of Drug Biotechnology

Answer»

Right answer is (b) Lipid soluble drugs

To elaborate: The intact Lipoidal membrane of the MICROSOME is essential for its selectivity towards lipid soluble substrates. The lipid soluble SUBSTRATE is bio transformed into water-soluble metabolite by the microsomal ENZYMES and thus can EASILY EXCRETE out.



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