The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.(a) α-helices, long-range, α-helices, short-range(b) α-helices, long-range, β-strands, short-range(c) α-helices, short-range, β-strands, long-range(d) β-strands, short-range, β-strands, long-rangeThe question was asked in exam.This intriguing question originated from Protein Secondary Structure Predictionfor Globular Proteins topic in chapter Secondary Structure Prediction of Bioinformatics

The formation of _____ is determined by ______ interactions, whereas t

1.	The formation of _____ is determined by ______ interactions, whereas the formation of ____ is strongly influenced by ______ interactions.(a) α-helices, long-range, α-helices, short-range(b) α-helices, long-range, β-strands, short-range(c) α-helices, short-range, β-strands, long-range(d) β-strands, short-range, β-strands, long-rangeThe question was asked in exam.This intriguing question originated from Protein Secondary Structure Predictionfor Globular Proteins topic in chapter Secondary Structure Prediction of Bioinformatics
Answer» RIGHT option is (c) α-helices, short-range, β-strands, long-range To explain I would say: PROTEIN secondary STRUCTURE prediction with high accuracy is not a trivial ask. It remained a very difficult problem for decades. This is because protein secondary structure elements are context dependent. The formation of α-helices is DETERMINED by short-range interactions, whereas the formation of β-strands is strongly influenced by long-range interactions. Prediction for long-range interactions is theoretically difficult. After more than three decades of EFFORT, prediction accuracies have only been improved from about 50% to about 75%.

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