The hierarchical clustering method generates a similarity score [S(X,Y)] for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.(a) True(b) FalseThe question was posed to me in an interview for internship.My enquiry is from Global Gene Regulation in section Genome Analysis of Bioinformatics

The hierarchical clustering method generates a similarity score [S(X,Y

1.	The hierarchical clustering method generates a similarity score [S(X,Y)] for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.(a) True(b) FalseThe question was posed to me in an interview for internship.My enquiry is from Global Gene Regulation in section Genome Analysis of Bioinformatics
Answer» The correct answer is (a) True The best explanation: The DISADVANTAGE of this method is that it fails to discriminate between different patterns of variation. For example, a GENE expression pattern for which a HIGH value is found at an intermediate time point will be clustered with ANOTHER for which a high value is found at a late time point in the experiment. These variations have to be separated in a subsequent STEP.

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