The hierarchical genome sequencing approach is ______(a) entirely dissimilar to the shotgun approach(b) dissimilar to the shotgun approach(c) similar to the shotgun approach, but on a larger scale(d) similar to the shotgun approach, but on a smaller scaleThis question was posed to me in quiz.My doubt is from Genome Sequencing topic in division Genome Mapping, Assembly and Comparison of Bioinformatics

The hierarchical genome sequencing approach is ______(a) entirely diss

1.	The hierarchical genome sequencing approach is ______(a) entirely dissimilar to the shotgun approach(b) dissimilar to the shotgun approach(c) similar to the shotgun approach, but on a larger scale(d) similar to the shotgun approach, but on a smaller scaleThis question was posed to me in quiz.My doubt is from Genome Sequencing topic in division Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Correct option is (d) similar to the shotgun approach, but on a smaller scale The explanation: In this, the chromosomes are INITIALLY MAPPED using the physical mapping strategy. Longer fragments of genomic DNA (100 to 300 kB) are OBTAINED and cloned into a high-capacity bacterial vector called bacterial artificial chromosome (BAC).

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