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The last step in structure classification involves grouping proteins/domains of similar structures.(a) True(b) FalseThis question was addressed to me during an interview for a job.My query is from Protein Structure Classification in division Structural Bioinformatics of Bioinformatics

Answer»

Correct OPTION is (a) True

Explanation: Once multidomain proteins are split into separate DOMAINS, structure comparison can be conducted at the domain level, either through manual INSPECTION, or automated structural alignment, or a combination of both. This STEP involves GROUPING proteins/domains of similar structures and clustering them based on different levels of resemblance in secondary structure composition and arrangement of the secondary structures in space.



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