The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure.(a) only(b) not at all(c) partially(d) neverI have been asked this question at a job interview.I'd like to ask this question from Limitations of Prediction in portion RNA Structure Prediction of Bioinformatics

The Second assumption in predicting RNA secondary structure is that th

1.	The Second assumption in predicting RNA secondary structure is that the energy associated with any position in the structure is _____ influenced by local sequence and structure.(a) only(b) not at all(c) partially(d) neverI have been asked this question at a job interview.I'd like to ask this question from Limitations of Prediction in portion RNA Structure Prediction of Bioinformatics
Answer» Right answer is (a) only Explanation: The energy ASSOCIATED with a particular base pair in a double-stranded region is assumed to be influenced only by the previous base pair and not by the base pairs farther down the double-stranded region or anywhere else in the structure. These energies can be reliably ESTIMATED by EXPERIMENTATION with small, synthetic RNA oligonucleotides recently IMPROVED to include sequence DEPENDENCE.

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