The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.(a) True(b) FalseThis question was addressed to me during an interview for a job.This interesting question is from Genome Sequencing topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics

The shotgun approach does not require knowledge of physical mapping of

1.	The shotgun approach does not require knowledge of physical mapping of the clone fragments, but rather a robust computer assembly program to join the pieces of random fragments into a single, whole-genome sequence.(a) True(b) FalseThis question was addressed to me during an interview for a job.This interesting question is from Genome Sequencing topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Correct option is (a) True To explain: Generally, the genome has to be redundantly sequenced in such a way that the overall length of the fragments covers the entire genome multiple times. This is designed to MINIMIZE SEQUENCING errors and ensure correct assembly of a CONTIGUOUS SEQUENCE. Overlapping SEQUENCES with an overall length of six to ten times the genome size are normally obtained for this purpose.

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