The shotgun approach _______ sequences clones from _____ of cloned DNA.(a) randomly, one end(b) randomly, both ends(c) specifically, both ends(d) specifically, one endThis question was addressed to me by my college director while I was bunking the class.This question is from Genome Sequencing topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics

The shotgun approach _______ sequences clones from _____ of cloned DNA

1.	The shotgun approach _______ sequences clones from _____ of cloned DNA.(a) randomly, one end(b) randomly, both ends(c) specifically, both ends(d) specifically, one endThis question was addressed to me by my college director while I was bunking the class.This question is from Genome Sequencing topic in chapter Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» CORRECT option is (b) randomly, both ends For EXPLANATION I would say: There are two major strategies for whole genome SEQUENCING: the shotgun approach and the hierarchical approach. The shotgun approach generates a large number of SEQUENCED DNA fragments. The number of random fragments has to be very large, so large that the DNA fragments overlap sufficiently to cover the entire genome.

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