What is the function of somatostatin?(a) Inhibits histamine and gastrin-releasing cells(b) Activates histamine and gastrin realising cells(c) Inhibits H+ secretion(d) Ensures H+ secretionThis question was posed to me in an international level competition.Asked question is from Pharmacotherapy of Peptic Ulcer topic in portion Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

What is the function of somatostatin?(a) Inhibits histamine and gastri

1.	What is the function of somatostatin?(a) Inhibits histamine and gastrin-releasing cells(b) Activates histamine and gastrin realising cells(c) Inhibits H+ secretion(d) Ensures H+ secretionThis question was posed to me in an international level competition.Asked question is from Pharmacotherapy of Peptic Ulcer topic in portion Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology
Answer» Right option is (a) Inhibits histamine and gastrin-RELEASING cells Explanation: Somatostatin releasing cells inhibits the histamine and gastrin releasing cells and THUS regulates the secretion. Vagus nerve provides a SIGNAL which stimulates histamine releasing cells i.e. enterochromaffin cells. Acetylcholine works on acetylcholine receptors and leads to H+ ions release. Gastrin releasing cells release gastrin which further AID the process.

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