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Which coenzyme is synthesized in the 1st step of the formation of Glucuronide?(a) Uridine triphosphate(b) Uridine-5’-diphosphate-alpha-D-glucuronic acid(c) UDP-glucose(d) GlucuronideI have been asked this question by my college director while I was bunking the class.I need to ask this question from Drugs Biotransformation topic in division Biotransformation of Drugs of Drug Biotechnology

Answer»

The correct ANSWER is (b) Uridine-5’-diphosphate-alpha-D-glucuronic acid

Easiest explanation: Glucuronide formation takes place in 2 STEPS. The 1st STEP activated coenzyme uridine-5’-diphosphate-alpha-D-glucuronic acid is FORMED from UDP-glucose. The coenzyme ACTS as a donor of glucuronic acid.



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