Which of the following is incorrect?(a) Initial DNA sequencing reactions generate short sequence reads from DNA clones(b) To assemble a whole genome sequence, these short fragments are joined to form larger fragments(c) The average length of the reads is about 50 bases(d) A number of overlapping contigs can be further merged to form scaffoldsI got this question in examination.Question is taken from Genome Sequence Assembly topic in division Genome Mapping, Assembly and Comparison of Bioinformatics

Which of the following is incorrect?(a) Initial DNA sequencing reactio

1.	Which of the following is incorrect?(a) Initial DNA sequencing reactions generate short sequence reads from DNA clones(b) To assemble a whole genome sequence, these short fragments are joined to form larger fragments(c) The average length of the reads is about 50 bases(d) A number of overlapping contigs can be further merged to form scaffoldsI got this question in examination.Question is taken from Genome Sequence Assembly topic in division Genome Mapping, Assembly and Comparison of Bioinformatics
Answer» Correct answer is (c) The average length of the reads is about 50 bases The BEST I can explain: The average length of the reads is about 500 bases. To assemble a whole GENOME sequence, these short fragments are joined to form LARGER fragments after removing overlaps. These longer, merged sequences are termed contigs, which are usually 5,000 to 10,000 bases long. A number of OVERLAPPING contigs can be further merged to form scaffolds (30,000–50,000 bases, also called supercontigs), which are unidirectionally oriented along a physical map of a chromosome.

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