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Which of the following is incorrect about SSAP?(a) It is a web server that uses an intramolecular distance–based method(b) Matrices are built based on the Cβ distances of all residue pairs(c) Dynamic programming approach is not used here(d) Dynamic programming approach is usedI have been asked this question in an interview.Question is taken from Protein Structure Comparison in division Structural Bioinformatics of Bioinformatics

Answer»

Correct option is (c) DYNAMIC programming approach is not used here

Easy explanation: When comparing two different matrices, a dynamic programming approach is used to find the path of residue positions with optimal SCORES. The dynamic programming is applied at two LEVELS, one at a lower level in which all residue pairs between the proteins are compared and another at an upper level in which subsequently identified equivalent residue pairs are processed to refine the matching positions. An SSAP score is reported for structural SIMILARITY. A score above 70 indicates a good structural similarity.



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