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Which of the following is incorrect about the intramolecular approach?(a) The method works by generating a distance matrix between residues of the same protein(b) It generates a string between residues of the same protein(c) In comparing two protein structures, the distance matrices from the two structures are moved relative to each other to achieve maximum overlaps(d) By overlaying two distance matrices, similar intramolecular distance patterns representing similar structure folding regions can be identifiedI got this question during an online interview.My question comes from Protein Structure Comparison topic in division Structural Bioinformatics of Bioinformatics

Answer»

The CORRECT choice is (b) It generates a string between residues of the same protein

For explanation I would say: For the ease of comparison, each matrix is decomposed into smaller SUBMATRICES consisting of hexapeptide fragments. To maximize the similarity regions between two structures, a MONTE Carlo procedure is used. By reducing three-dimensional information into two-dimensional information, this strategy IDENTIFIES overall structural resemblances and common structure CORES.



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